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Órgano oficial de la Asociación Mexicana de Medicina Transfusional A.C.

2018, Number 1

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Rev Mex Med Transfus 2018; 11 (1)

Coagulopathy and management of hemocomponents in patients with massive transfusion in a university hospital

Cruz CBl, Pérez CF, Cázares TR, Mercado-Del Ángel F

Language: Spanish
References: 12
Page: 5-10
PDF size: 177.93 Kb.


ABSTRACT

Background: Massive hemorrhage causes a mortality of 50% in patients that require massive transfusion. Adequate resuscitation with transfusions during the acute phase increases survival 10 to 15%; however, 25% of patients develop coagulopathy. Objective: To identify patients with massive transfusions who develop coagulopathy and the relationship with blood products transfused during the acute event. Material and methods: Data of 90 patients with massive transfusion were collected and patients with criteria of coagulopathy and the blood products transfused were analyzed; likewise, diagnosis on admission, type of lesion, pH, systolic blood pressure, and mortality at 24 hours and 30 days were recorded. Results: A coagulopathy was identified in 37 patients (18.9%); in this group, a mortality of 71.4% was detected. Patients with a hemoglobin of ‹ 6 g/dL, more prolonged coagulation times, a low pH (≤ 7.25) and who deviated from a packed red cells: fresh frozen plasma: platelet concentration 1:1:1 ratio had a greater mortality at 24 hours. Conclusions: In our population, one-fifth of patients who require a massive transfusion develop a coagulopathy. A greater risk was found in patients with inadequate transfusion management.


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