Hernández PJE, Domínguez TG, Morales PJD, Robles TA, Pérez CA

Language: English
References: 11
Page: 188-192
PDF size: 238.06 Kb.

ABSTRACT

Infective endocarditis affects multiple systems, and is usually from a bacterial infection of the endocardial surface of the heart. Neurologic complications occur in 20 to 40 percent of patients and are associated with a higher mortality rate. This case is from a 37-year-old man with a history of chronic lower back pain and chronic use of intravenous opioids (tramadol), who suddenly experienced disorientation, drowsiness, and aphasia. At admission, he presented fever of 38 oC, heart rate of 115 bpm, blood pressure 100/60 mmHg and breathing rate of 24 rpm. The physical examination revealed a IV/VI holosystolic murmur over the apex, radiating to the axilla, as well as Osler nodes and Janeway lesions at cutaneous level. The rest of the physical and neurological examination did not present any abnormalities. Fluid infusion and empirical antibiotic therapy were started (vancomycin and ceftriaxone). Cranial tomography did not show alterations and the echocardiogram revealed severe mitral regurgitation and a 1 × 0.9 cm-sized vegetation on the anterior leaflet of the mitral valve. Laboratory tests reported: leukocytosis of 23,000/mm³, platelets of 108,000/mm³. The cerebrospinal fluid analysis showed: turbid appearance, glucose of 32 mg/ dL, proteins of 165 mg/dL, lymphocytes of 0, leukocytes of 1,760/mm3, data compatible with bacterial meningitis, as well as culture at 72 hours with Staphylococcus aureus isolation. After 72 hours of admission, he presented deterioration of mental status and respiratory failure, so mechanical ventilation support was initiated. Because of the risk of embolism, mitral valve replacement was performed and after improvement, he was extubated without complications or sequelae. This case highlights the importance of associating risk factors with a thorough physical examination, essential to establish the diagnosis approach and timely treatment of infective endocarditis with systemic involvement.

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