González TR, Díaz LA, Trimiño GL, Suárez GA, Guardarrama LL, Acosta GFA

Language: Spanish
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ABSTRACT

Introduction: Polycystic ovary syndrome is the most common ovulatory disorder among women of childbearing age. It is associated to metabolic disorders which might in turn be related to hyperandrogenism.
Objective: Identify the metabolic disorders among women with polycystic ovary syndrome and their relationship to hyperandrogenism.
Methods: A cross-sectional descriptive study was conducted at the Low- Technology Assisted Reproduction Center in Matanzas from December 2016 to June 2017. The study included all the women attending infertility consultation who met the Rotterdam criteria for polycystic ovary syndrome diagnosis (n = 38). General data and information on personal pathological antecedents were collected and physical examination performed. The glucose tolerance test was applied and determination was made of values for follicle-stimulating hormone, luteinizing hormone, prolactin, testosterone, insulin, glycemia, glycated hemoglobin, triglycerides, total cholesterol, high-density lipoprotein cholesterol, creatinine and uric acid. HOMA-IR was estimated and metabolic syndrome carriers were identified. Two groups were formed for statistical analysis: one with hyperandrogenism (n = 17) and one without hyperandrogenism (n = 21).
Results: Metabolic disorders were common across the series. Patients with hyperandrogenism had a higher frequency of obesity (82.4 %; p = 0.013), waist circumference ? 88 cm (94.1 %; p = 0.005), impaired glucose tolerance (41.2 %; p = 0.001) and hyperuricemia (17.6 %; p = 0.045).
Conclusions: Metabolic disorders were common in this group of patients. Hyperandrogenism carriers had more marked metabolic disorders than noncarriers, particularly as concerns impaired glucose tolerance and hyperuricemia, probably mediated by obesity.