Morel-Cerda EC, Velarde-Ruiz VJA, Álvarez-López F, García-Jiménez ES, Rangel-Orozco MF, González-Álvarez R, Flores-Mendoza JF, Zaragoza-Scherman CF, Velarde-Chávez JA, Mora-Huerta JA, Lazcano-Becerra M, Briones-Govea D, Pelayo Vélez CO, Ledesma-Vizcarra FM, Aldana-Ledesma JM

Language: Spanish
References: 9
Page: 113-118
PDF size: 608.59 Kb.

ABSTRACT

Introduction. Acute pancreatitis (AP) is an inflammatory condition of the pancreas that can cause local complications, systemic inflammatory response syndrome (SIRS) and organ failure (OF). Most cases of AP have a mild course, but those who progress to moderately severe and severe forms have a higher rate of morbidity and mortality. Previously, the presence of metabolic syndrome (MetS) has been related as a predictor of severity in patients with AP, but very few studies have evaluated nonalcoholic fatty liver disease (NAFLD) and its association with clinical outcomes.Our objective was to determine the prevalence of fatty liver in patients with AP. In addition, as secondary objectives, to determine if there is an association between fatty liver and the severity of AP.
Material and Methods. All patients diagnosed with AP hospitalized from January 2017 to June 2018 were included. Their clinical data, laboratory tests and imaging findings were collected from previous hospital discharge summaries and from the database of our institution. The prevalence of fatty liver was evaluated by abdominal ultrasound.
Results. During the period of study, there were 199 patients with PA. 62.8% of these were women; the average age of the individuals included was 41 years. The main etiology of pancreatitis was biliary (70%). In 26% of the included patients, criteria for MetS were met and 36.5% presented hepatic steatosis. 11% of patients with MetS had fatty liver. 14.6% had a diagnosis of diabetes mellitus, as well as 14% of arterial hypertension; while 39% of the population had obesity. Of the patients with fatty liver, 25% presented severe PA by APACHE II and 7% persistent FO. Transient and persistent SIRS presented with equal frequency in both groups, as severe BP was not associated with fatty liver. In-hospital mortality was 1.5%.
Discussion. The prevalence of fatty liver in patients with AP is higher in our population than that reported in the literature, therefore more studies are needed to determine associated risk factors. There was no statistically significant difference between the presence of fatty liver, pancreatic necrosis, nor severity of AP.

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