medigraphic.com
ISSN 0001-0944 (Print)
Órgano Oficial de la Asociación Dental Mexicana

2019, Number 1

<< Back

Rev ADM 2019; 76 (1)

Central giant cell lesion in mandibular. Report of a case and review of literature

Carrasco RC, Vinitzky BI, Aldape BB

Language: Spanish
References: 19
Page: 49-54
PDF size: 361.05 Kb.


ABSTRACT

The term central giant cell lesion describes a group of non-odontogenic benign intraosseous tumors that histologically contain giant cells. Various entities in the jaws may share this histological feature including hyperparathyroidism, cherubism, and central giant cell granuloma. It can be classified as: aggressive and non-aggressive, based on clinical and radiographic characteristics. Traditional treatment has been surgical excision, the extension of which can vary from simple curettage to block resections, the use of curettage combined with cryotherapy or peripheral ostectomy has also been reported. Recurrence rates after surgical treatment range from 11 to 49%; however, in aggressive lesions, rates of up to 72% have been reported. We present a case of a patient with a central giant cell lesion with aggressive behavior was treated with surgical resection with a favorable outcome.


REFERENCES

  1. Austin LT Jr, Dahlin DC, Royer RQ. Giant-cell reparative granuloma an related conditions affecting the jawbones. Oral surg Oral Med Oral Pathol. 1959; 12: 1285.

  2. Peacock Z, Jordan R, Schmidt B. Giant cell lesions of the jaws: does the level of vascularity and angiogenesis correlate with behavior? J Oral Maxillofac Surg. 2012; 70: 1860-1866.

  3. Peacock ZS, Resnick CM, Susarla SM, Faquin WC, Rosenberg AE, Nielsen GP, Schwab JH, Hornicek F, Ebb DH, Dodson TB, Kaban LB. Do histologic criteria predict biologic behavior of giant cell lesions? J Oral Maxillofac Surg. 2012; 70 (11): 2573-2580.

  4. Nogueira RLM, Osterne RLV, Cavalcante RB, Teixeira R. Surgical treatment, oral rehabilitation, and orthognatic surgery after failure of pharmacologic treatment of central giant cell lesion: a case report. J Oral Maxillofac Surg. 2016; 74: 2567 e1-2567e10.

  5. Lange J, Akker H. Clinical and radiological features of central giant-cell lesions of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 99: 464-470.

  6. Jaffe HL. Giant-Cell reparative granuloma, traumatic bone cyst, and fibrous dysplasia of the jaw bones. Oral Surg. 1953; 6: 159-175.

  7. Chuong R, Kaban LB, Kozakewich H, Perez-Atayde A. Central giant cell lesions of the jaws: a clinicopathologic study. J Oral Maxillofac Surg. 1986; 44: 708.

  8. Valentine JC, Nelson BL. Central giant cell lesion. Head and Neck Pathol. 2011; 5: 385-388.

  9. O’Conell JE, Bowe C, Murphy C, Toner M, Kearns G. Aggressive giant lesion of the jaws: a review of management options and report of a mandibular lesion treated with denosumab. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120: 191-198.

  10. Nogueira RL, Faria MH, Osterne RL, Cavalcante RB, Ribeiro RA, Rabenhorst SH. Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy. Int J Oral Maxillofac Surg. 2012; 41: 994-1000.

  11. Webb DJ, Brockbank J. Combined curettage and cryosurgical treatment for the aggressive “giant cell lesion” of the mandible. Int J Oral Maxillofac Surg. 1986; 5: 780.

  12. Nogueira RL, Faria MH, Osterne RL, Cavalcante RB, Ribeiro RA, Rabenhorst SH. Central giant cell granuloma of the jaws: experience in the management of thirty seven cases. J Oral Maxillofac Surg. 1988; 46: 376-384.

  13. Flanagan AM, Nui B, Tinkler SM, Horton MA, Williams DM, Chambers TJ. The multinucleate cells in the giant cell granulomas of the jaw are osteoclasts. Cancer. 1988; 62: 1139.

  14. Pogrel MA. Calcitonin therapy for central giant cell granuloma. J Oral Maxillofac Surg. 2003; 61: 649-653.

  15. Kaban LB, Mulliken JB, Ezekowitz RA, Ebb D, Smith PS, Folkman J. Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alpha-2a. Pediatrics. 1999; 103: 11145-11149.

  16. Vinitzky-Brener I, Ibáñez-Mancera NG, Aguilar-Rojas AM, Álvarez-Jardón AP. Knowledge of bisphosphonate-related osteonecrosis of the Jaws among Mexican dentists. Med Oral Patol Oral Cir Bucal. 2017; 22 (1): e84-e87.

  17. Terry BC, Jacoway JR. Management of central giant cell lesions-An alternative to surgical therapy. Oral Maxillofac Surg Clin North Am. 1994; 6: 579.

  18. Jiménez R, Benavides A. La estereolitografía en la facultad de odontología de la UNAM. 2005; 9 (5): 48-50.

  19. Anderl H, Zur Nedden D, Mühlbauer W, Twerdy K, Zanon E, Wicke K, Knapp R. CT-guided stereolithography as a new tool in craniofacial surgery. Br J Plast Surg. 1994; 47 (1):60-64.




2020     |     www.medigraphic.com