Montalvo SE, Domínguez ÁC, Meunier M, Peña NBR

Language: Spanish
References: 28
Page: 17-29
PDF size: 176.66 Kb.

ABSTRACT

Introduction: squamous cell carcinoma is the third most common malignant gastrointestinal neoplasm. In Cuba, there are about 448 cases of esophageal cancer per year and the incidence is 4.3 per 100 000 inhabitants. Objective: to identify the presence of human papilloma virus in biopsies of esophageal squamous carcinoma. Method: descriptive cross-sectional study in 42 esophageal biopsies with microscopic diagnosis of Squamous Esophageal Carcinoma, from the Pathological Anatomy Service of Hermanos Ameijeiras Hospital, January / 2014-December / 2015, analyzed by the Polymerase Chain Reaction and Immunohistochemistry. Demographic and histopathological variables were explored, relative frequencies were calculated and the association between variables was assessed using chi-square. Results: those over 60 years old, male (76.2%), whites (54.8%) and moderately differentiated tumors (47.6%) predominated; 45.25% were located in the middle third of the esophagus. The Human Papilloma Virus was detected in 28.6% of the biopsies according to the Polymerase Chain Reaction, 19% expressed p16. No association was found between age, sex and tumor location. The Polymerase Chain Reaction showed significant differences regarding the degree of tumor differentiation. Conclusions: in the samples with esophageal squamous cell carcinoma, the presence of HPV was found in a low percentage, with predominance of males, over 60 years of age, whites.

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