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2019, Number 1

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Dermatología Cosmética, Médica y Quirúrgica 2019; 17 (1)

Histopathological Features of Hemosiderotic and Aneurismatic Dermatofibroma: Report of Three Cases and Review of the Literature

Zetina G, Salgado C, Camacho S, Helga MS
Full text How to cite this article

Language: Spanish
References: 10
Page: 16-20
PDF size: 262.72 Kb.


Key words:

hemosiderotic dermatofibroma, aneurysmal dermatofibroma, hemosiderin, multinucleated cells.

ABSTRACT

Dermatofibroma is a common benign fibrohistiocytic tumor, usually observed in adults, with a slight predominance in females, usually located in lower limbs. The cause of dermatofibroma is still unknown, but it is widely accepted that dermatofibroma may result from a trauma, such as an insect bite, rupture of a follicle, or a follicular cyst. They present multiple variants; some of them are infrequent in clinical practice. The hemosiderotic dermatofibroma is a rare variant, with well-defined clinical and histological patterns but little reported in the literature or reported as synonymous with the aneurysmal dermatofibroma. We present two clinical cases of hemosiderotic dermatofibromas in female patients between 25 and 30 years old, with clinical evolution of 12 and eight months respectively; the report of an aneurysmal dermatofibroma in a 40-year-old female patient is also presented. The review of the literature is performed as uncommon variants of dermatofibromas.


REFERENCES

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  2. Achenbach R, Maggi C, Oliveira G et al., Dermatofibroma polipoideo gigante palmar, Revista Argentina de Dermatología 2014; 95(1):1-5.

  3. Villareal D, Tanus A, Mota A et al., Hemosiderotic dermatofibroma, Anais Brasileiros de Dermatología 2017; 92(1):92-4.

  4. Navarrete G, González M, Elia Espinosa C, Dermatofibroma aneurismático, Revista Mexicana de Dermatología 2007; 51(3):117-20.

  5. Alves JV, Matos DM y Barreiros HF, Variants of dermatofibroma: a histopathological study, Anais Brasileiros de Dermatologia 2014; 89(3):472-7.

  6. Beer T, Lam M y Heenan P, Tumors of fibrous tissue involving the skin. En Lever’s Histopathology of the Skin, Filadelfia, Wolters Kluwer 2008, pp. 969-77.

  7. Chen TC, Kuo T y Chan HL, Dermatofibroma is a clonal proliferative disease, J Cutan Pathol 2000; 27(1):36-9.

  8. Plaszczyca A, Nilsson J, Magnusson L et al., Fusions involving protein kinase c and membrane-associated proteins in benign fibrous histiocytoma, Int J Biochem Cell Biol 2014; 8:1-7.

  9. Zaballos P, Llambrich A, Ara M et al., Dermoscopic findings of haemosiderotic and aneurysmal dermatofibroma: report of six patiens, British Journal of Dermatology 2005; 154:244-50.

  10. Senel E y Yuyucu K, Clinical, histopathological, dermatoscopic and digital microscopic features of dermatofibroma: a retrospective analysis of 200 lesions, Journal of the European Academy of Dermatology and Venereology 2015; 29:1958-66.




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C?MO CITAR (Vancouver)

Dermatología Cosmética, Médica y Quirúrgica. 2019;17