2019, Number 1
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ABSTRACTWhen it was catalogued as a vitamin and classified as a dispensable nutrient, its function was left for a limited time to the bone metabolism and its associated diseases at that level, however, at the beginning of this century, the genomic activity in which vitamin D was related was described, as well as the direct and rapid effects it caused at the molecular level, modifying cellular responses in different fields and in different metabolic steps, so it was observed its effect as a context at the cellular level and now as a cause of disease as such, so it has motivated its study in different diseases to different organs and systems, so now there is a review of its role on health and disease in the immune system. And we also describe how difficult it is to obtain from the daily intake, as well as to describe the most current recommended doses in their deficiency and in a disease.
Takeda M, Yamashita T, Sasaki N, Nakajima K, Kita T, Shinohara M et al. Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions. Arterioscler Thromb Vasc Biol. 2010; 30 (12): 2495-2503.