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ISSN 2007-6800 (Print)

2019, Number 1

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Rev Mex Traspl 2019; 8 (1)

Adherence to immunotherapy kidney transplant recipients in a tertiary care center in Mexico

Cruz-Santiago J, Noriega-Salas L, Robledo-Meléndez A, Bernáldez-Gómez G, García-Ramírez C, Meza-Jiménez G, Rivera-Luna E, Díaz-Franco MC

Language: Spanish
References: 21
Page: 5-13
PDF size: 263.84 Kb.


ABSTRACT

Introduction: Kidney transplantation is the treatment of choice for patients with end-stage renal disease, since it is associated with greater patient survival, a better quality of life. Adequate compliance with immunosuppressive therapy is essential in this type of patient, since non-adherence to treatment is the major risk factor for acute rejection and loss of the graft. With the objective of evaluating the adherence of our kidney transplant recipients at the Hospital de Especialidades Centro Médico Nacional La Raza, we applied a questionnaire, analyzing and evaluating the results. Material and methods: With an exploratory, analytical and transversal design, a sample size was determined at convenience; which included patients undergoing renal transplantation, over 18 years of age, in the period of five months who agreed to participate in the study. The patients were evaluated by means of a questionnaire, elaborated with variables of the transplanted organ, the immunotherapy and the evaluation of the adherence to the treatment. With the results, a multivariate model was created to determine the statistical significance of the variables. Results: In a total of 400 patients, a frequency of non-adherence of 5.49% was found. The factors with statistical significance were the perception that the immunosuppressant medication is harmful, OR = 5.53 (p = 0.002), in addition to the interruption of the secondary medication intake to feeling of sadness, OR = 9.43 (0.001). Conclusions: Lack of adherence is a problem that affects the prognosis of kidney transplantation; since it is associated with a higher incidence of antibody-mediated rejection, it is therefore of vital importance to detect this, since the implementation of the kidney transplant protocol and the search for factors that could favor the appearance of this entity, in the post-transplant immediate, and throughout the follow-up of the kidney transplant carrier.


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