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2006, Number 4

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Rev Mex Pediatr 2006; 73 (4)

Oral sildenafil as an alternative treatment in the persistent pulmonary hypertension in newborns

Herrera TR, Concha GP, Holberto CJ, Loera GRG, Rodríguez BI

Language: Spanish
References: 33
Page: 159-163
PDF size: 53.85 Kb.


ABSTRACT

Objective: To compare the conventional management of newborn children with persistent pulmonary hypertension (PPH) using sildenafil or not.
Material and methods: 13 neonates with (PPH) were chosen randomly, they received oral sildenafil (Viagra®): 2 mg/kg each 6 hours and ventilation. By the same way other 11 neonates were chosen, they received the same management but not sildenafil. Oxygenation index and medium airway pressure were monitored; was also obtained information about frequency of pneumothorax and the life prognosis.
Results: The neonates treated with sildenafil improved the oxygenation index since 24 h after the first doses, diminishing the alveolus-arterial gradient. It made possible decrease the ventilation parameters and the medium airway pressure. The frequency of pneumothorax and death was lower in the group of sildenafil.
Conclusion: The oral administration of sildenafil in newborns with PHH is a good alternative in the hospitals that don’t count with oxidize nitric neither high oscillatory frequency.


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