2019, Number 1
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Rev Clin Esc Med 2019; 9 (1)
“Defectos del Tubo Neural: Factores de Riesgo Etiológico.”
Flores SG
Language: Spanish
References: 12
Page: 65-71
PDF size: 216.71 Kb.
ABSTRACT
The defects of the neural tube are serius congenital
malformations whose prenatal diagnosis allows to
guide the obstetric management, this can also increase
the expectations of the users of the medical services
and increase even more the existing complexity in
the analysis of the causal link in forensic analysis of
complaints about professional responsibility, and
justifies the updating of concepts about the etiological
risk factors of these defects, which are identified in the
recent scientific medical literature. With this objective,
this review is carried out, obtaining that the etiology
of most neural tube defects seems to be multifactorial
and involves genetic and environmental factors and
probably requires the contribution of more than one
element, so it is not possible to relate directly to a
single factor, such as the lack of folic acid supplement
during the prenatal period, with a malformation of
this type, or rule out other causes, in addition to many
of the molecular mechanisms are still under study. In
establishing the causal link there must be sufficient
evidence to fully accept that there is a direct relationship
between non-exposure or exposure to a factor and
the clinical effect (outcome). It is hoped that the
discovery of new genes and epigenetic factors related
to the defect will produce new preventive approaches;
improved genetic counseling; and improved prognostic
information and new therapeutic strategies, for which
the forensic medical analysis will increase in complexity
if complaints are established in this regard.
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