Mercado U

Language: Spanish
References: 0
Page: 425-428
PDF size: 165.03 Kb.

ABSTRACT

Rheumatoid arthritis is a systemic, inflammatory disease characterized by chronic synovitis and presence of autoantibodies. Risk factors include HLA-DRb1 genes, periodontal disease and smoking. At least 5 different autoantibodies to autoantigens are implicated in the pathogenesis of this disorder: 1) rheumatoid factor; 2) autoantibodies directed against citrullinated peptides/proteins (ACPA); 3) anti-carbamilated protein antibody (anti-carP); 4) anti-peptidylarginine deiminase antibody (anti-PAD2/4), and 5) anti-citrullinated fibrinogen antibody. Patients with rheumatoid arthritis have been divided into two disease subsets: ACPA-positive rheumatoid arthritis and ACPA-negative rheumatoid arthritis. ACPA-positive rheumatoid arthritis is associated with HLA-DRb1 shared epitope alleles and is recognized by antigen-specific T cells and B cells.