2019, Number 2
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ABSTRACTAndrogenetic alopecia (AGA), commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men, and the main reason for dermatological consultation. aga features a progressive miniaturization of the hair follicle; its incidence and prevalence depends on age and ethnicity. The treatments available are minoxidil and oral treatment with 5-alpha reductase inhibitors (finasteride, dutasteride) but results are observed in a long-term period, plus, they depend on the patient’s attachment and often tend to be discontinued. That’s why research must now aim at developing treatments with better results. The efficacy of dutasteride in mesotherapy has been studied since 2008, nevertheless, it has demonstrated excellent outcomes, there is no uniformity among the application therapy protocols.
Objective: the objective of the present article is to describe the outcomes of five male patients with AGA classified as IV to VI in the Hamilton-Norwood scale, treated with dutasteride microinjections.
Methods: a retrospective study was conducted, it included five patients who were diagnosed with aga. All of them were treated with 1 ml of intradermal dutasteride at 0.01% during six months with one-session treatment every three months. Simultaneously, they received topical therapy using minoxidil. Assesment of the response was done using both, photographs and the Hamilton-Norwood scale.
Results: all patients increased the diameter of the existing hair and no side effects were reported.
Conclusion: dutasteride in mesotherapy proves to be an alternative for treating Mexicans with aga and outcomes can be evaluated in the mid-term.
Olsen EA, Hordinsky M, Whiting D, Stough D, Hobbs S, Ellis ML et al., The importance of dual 5-alpha reductasa inhibition in the treatment of male pattern hair loss: results of a randomized, double blind, placebo- controlled, phase iii study of dutasteride vs finasteride, J Am Acad Dermatol 2006; 55:1014-23.