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2019, Number 2

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Cardiovasc Metab Sci 2019; 30 (2)

G-proteins coupled receptors

Nájera N, Martínez‑Vega RP, Portilla‑Martínez A, Ortiz‑Vilchis P, Ceballos G

Language: English
References: 69
Page: 50-59
PDF size: 340.73 Kb.


Text Extraction

Introduction

The membrane receptors (GPCRs) coupled to regulatory binding proteins (G proteins), also known as R7G (receptors with 7 transmembrane domains, coupled to guanine nucleotide G proteins (Figure 1), heptahelical or serpentine receptors, form a large and ubiquitous protein superfamily, in charge of fundamental cellular functions. In humans, more than 800 of such receptors have been cloned, although a great proportion of them remains orphaned (without known ligand), while many others have been poorly, structurally and functionally, characterized.


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