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2019, Number 3

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Gac Med Mex 2019; 155 (3)

Alelos HLA más comunes y asociados con riesgo o protección en enfermedad renal crónica de etiología no determinada

Hernández-Rivera JCH, Salazar-Mendoza M, Pérez-López MJ, González-Ramos J, Espinoza-Pérez R, Martínez-Álvarez JC, Trejo-Villeda M, Paniagua-Sierra R

Language: Spanish
References: 26
Page: 243-248
PDF size: 142.14 Kb.


ABSTRACT

Introduction: Chronic kidney disease accounts for part of overall health expenditure; a potential etiology is related to variations, absence or presence of some human leukocyte antigen (HLA) alleles. Method: An analysis of HLA reports of 1965 kidney recipients with no determined etiology, and 1361 kidney donors was performed. It was carried out with Luminex based in cell flow fluorometry for the A, B, DRB1 and DQA loci. An analysis was performed with contingency tables in order to determine the odds ratio (OR) and confidence intervals (CI). Quantitative analysis was also carried out. Results: Of the 101 alleles found, 13 showed association, 7 with risk for chronic kidney disease, with the most significant being HLA-DR17 with an OR of 3.91 (95 % CI = 2.96-5.17) and the one with the highest significance for protection being HLA-DR9, with an OR of 0.043 (95 % CI = 0.005-0.3224). Conclusions: It is necessary to understand that kidney diseases can be associated with yet unknown immune processes, where the association of the absence or presence of any allele should be known.


REFERENCES

  1. Dehesa E. Enfermedad renal crónica; definición y clasificación. El Residente. 2008;3:73-78.

  2. Méndez-Durán A, Méndez-Bueno F, Tapia-Yáñez T, Muñoz-Montes A, Aguilar-Sánchez L. Epidemiología de la insuficiencia renal crónica en México. Diálisis y Trasplante. 2001;31:7-11.

  3. Flores J. Enfermedad renal crónica: epidemiologia y factores de riesgo. Rev Med Clin Condes. 2010;21:502-507.

  4. Jadue N, González A. Inmunopatogenia de las enfermedades autoinmunes. Rev Med Clin Las Condes. 2012;23:464-472.

  5. Morera-Barrios LM, Verdura-González TE, Martínez-Legón Z, Ricardo- Lorenzo R. Asociación de antígenos HLA y enfermedades oftalmológicas. Rev Cubana Hematol Inmunol Hemoter. 2001;17:7-18.

  6. Tolosa A. Primer catálogo de enfermedades asociadas con variaciones en los genes de los antígenos leucocitarios humanos. España: Genética Médica; 2017.

  7. Corrales P, Corrales A, Carias S. Asociación entre HLA y enfermedad, estado actual y perspectivas. Rev Med Hondur. 1985;53:104-118.

  8. Fernández J. HLA y enfermedad. Rev Med Hondur. 1991;51:151-154.

  9. Fabiana P, Cech N, Fontan C, Giménez M, Lodeiro N, Marinic K, Molinari M, Sotelo M, Habegger A. Papel de las moléculas HLA-DR y HLA DQ en la lepra en la provincia del Chaco, Argentina. Enferm Infecc Microbiol Clin. 2007;25:627-631.

  10. Nachman P, Jannette J Falk R. Primary glomerular disease. En: Skorecki K, Chertow GM, Marsden PA, Taal MW. Brenner & Rector’s. The Kidney. EE. UU.: Elsevier; 2012.

  11. Klouda PT, Manos J, Acheson EJ, Dyer PA, Goldby FS, Harris R, et al. Strong association between idiopathic membranous nephropathy and HLA-DRW3. Lancet. 1979;2:770-771.

  12. Dyer PA, Klouda PT, Harris R, Mallick NP. Properdin factor B alleles in patients with idiopathic membranous nephropathy. Tissue Antigens. 1980;15 505-507.

  13. Layrisse Z, Rodríguez-Iturbe B, García-Ramírez R, Rodríguez A, Tiwari J. Family studies of the HLA system in acute post-streptococcal glomerulonephritis. Hum Immunol. 1983;7:177-185.

  14. Mori K, Sasazuki T, Kimura A, Ito Y. HLA-DP antigens and poststreptococcal acute glomerulonephritis. Acta Pediatr. 1996;85:916-918.

  15. Bakr A, Mahmoud LA, Al-Chenawi F, Salah A. HLA-DRB1* alleles in Egyptian children with post-streptococcal acute glomerulonephritis. Pediatr Nephrol. 2007;22:376-379.

  16. Fisher M, Pusey CD, Vaughan RW, Rees AJ. Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLADRB1 genes. Kidney Int. 1997;51:222-229.

  17. Huey B, McCormick K, Capper J, Ratliff C, Colombe BW, Garovoy MR, et al. Associations of HLA-DR and HLA-DQ types with anti-GBM nephritis by sequence-specific oligonucleotide probe hybridization. Kidney Int. 1993;44:307-312.

  18. Dunckley H, Chapman JR, Burke J, et al. HLA-DR and -DQ genotyping in anti-GBM disease. Dis Markers. 1991;9:249-256.

  19. Burns AP, Fisher M, Li P, Pusey CD, Rees AJ. Molecular analysis of HLA class II genes in Goodpasture’s disease. QJM. 1995;88:93-100.

  20. Kitagawa W, Imai H, Komatsuda A, Maki N, Wakui H, Hiki Y, et al. The HLA-DRB1*1501 allele is prevalent among Japanese patients with anti- glomerular basement membrane antibody-mediated disease. Nephrol Dial Transplant. 2008;23:3126-3129.

  21. Hernández-Rivera JCH, González-Ramos J, Pérez-López MJ, Carmona- Becerril A, Escárcega-Vázquez A, Cruz-Santiago J, et al. The most common HLA antigens found in patients with renal transplants at the specialties hospital of “La Raza” medical center, México. Transplant Proc. 2016;48:572-574.

  22. Contreras G, Lenz O, Pardo V, Borja E, Cely C, Iqbal K, et al. Outcome in African Americans and Hispanics with lupus nephritis. Kidney Int. 2006;69:1846-1851.

  23. Appel GB, Jayne D. Lupus nephritis. En: Johnson R, Floege J, Feehaly J, editores. Comprehensive clinical nephrology. EE. UU.: Elsevier; 2010.

  24. Gendi NS, Welsh KI, Van-Venrooij WJ, Vancheeswaran R, Gilroy J, Black CM. HLA type as a predictor of MCTD differentiation. Ten year clinical and immunogenetic follow-up of 46 patients. Arthritis Rheum. 1995;38:259-266.

  25. Diamantopoulos EJ, Andreadis EA, Vassilopoulos CV, Vlachonikolis IG, Tarassi KE, Chatzis N, et al. Association of specific HLA phenotypes with left ventricular mass and carotid intima-media thickness in hypertensives. Am J Hypertens. 2001;14:632-636.

  26. Waldman M, Madaio MP. Pathogenic autoantibodies in lupus nephritis. Lupus. 2005;14:19-24.




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