Use of adjuvants in postoperative pain&nbsp;&nbsp;

Ana Lilia Garduño-López; María Teresa Guizar-Rangel; Fabian Ernesto Torres-Muñoz; María Isabel Segura-Márquez; Julián David Londoño-Jiménez; Carlos Eduardo Medina-Sánchez; Víctor Manuel Acosta-Nava

2019, Number 3

Rev Mex Anest 2019; 42 (3)

Use of adjuvants in postoperative pain

Garduño-López AL, Guizar-Rangel MT, Torres-Muñoz FE, Segura-Márquez MI, Londoño-Jiménez JD, Medina-Sánchez CE, Acosta-Nava VM

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ABSTRACT

The adjuvant analgesics are compounds that have a low analgesic potency. However, with these compounds, the adverse effects of opioids may be diminished for the control of postoperative pain. Opioid-sparing strategies are related to the effect on a variety of receptors, of which we should name: the NMDA antagonists such as ketamine, magnesium and dextromethorphan, the α-2 agonists such as clonidine and dexmedetomidine, subunit α-2δ of calcium channels inhibitors; such as pregabalin and gabapentin, sodium channels blockers such as lidocaine and finally glucocorticoids. In this review we describe the characteristics, indications, doses and levels of evidence of use of adjuvants in the perioperative context (visit http://www.painoutmexico.com to see the full article and tables).