Medicina Cut嫕ea Ibero-Latino-Americana

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>Journals >Medicina Cut嫕ea Ibero-Latino-Americana >Year 2006, Issue 3

Galimberti G, Ferrario D, Galimberti D, Galimberti RL, Giusti C, Rodr璲uez CF
Excimer excilite. Advances in the use of 308 nm. monochromatic light in Dermatology
Med Cutan Iber Lat Am 2006; 34 (3)

Language: Espa隳l
References: 33
Page: 99-108
PDF: 547.54 Kb.

Full text


The advance in the therapeutic for some chronic dermatosis disease, lead to target new areas of action at molecular levels with the less damage on normal skin. The selective irradiation to the affected skin with 308-nm. UVB light to produce a local immunomodulator effect, decrease the T cells number in epidermic and dermic level. As UVB narrow-band, this delivery system is usefulla for the treatment of some localized chronic dermatosis such as psoriasis, vitiligo, eczemas, alopecia areata, skin lymphoma (mycosis fungoide, stage 1A), liquen and so on. The 308-nm. laser/lamp offers some advances over current therapy modalities in the treatment of localized dermatosis: they can treat exclusively afectted skin, with less risk for the uninvolved surrounding skin, higher dose-increase schemes, leading to faster healing and reduced cumulative dosis. We present the 308-nm. monochromatic light excimer excilite and its indications in dermathology.

Key words: excimer, MEL 308 nm., chronic dermatitis.


  1. Zanolli M. Phototherapy arsenal in the treatment of psoriasis. Dermatol Clin 2004; 22: 397-406.

  2. Morison WL, Parrish JA, Block KJ. In vivo effect of UVB on lymphocyte function. Br J Dermatol 1979;101:513-9.

  3. Takeshi Horio. Indication and action mechanisms of phototherapy. J Dermatol Sci 2000;23:17-21.

  4. Toews GB, Bergstresser PR, Streilein JW. Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follwing skin painting with DNFB. J Immunol 1980;124:445-53.

  5. Lugar T A, Schwartz T A. Effects of UV light on cytokines and neuroendocrines hormones. Photoimmunology 1995:55-76.

  6. Enk AH, Angeloni V, Vdey MC, Katz SI. Inhibi t ion of Langerhans cel ls antigen≧presenting function by IL-10: a role for IL-10 in induction of tolerance. J Immunol 1993;151 :2390-8.

  7. Lugar TA. Immunomodulation by UV light; role of neuropeptides. Eur J Dermatol 1998;8: 198-9.

  8. Chung HT, Burnham DK, Robertson B, Roberts LK, Daynes RA. Involvement of prostaglandins in the immune alterations caused by the exposure of mice to ultraviolet radiation. J Immunol 1986;137:2478-84.

  9. Bianchi B, Campolmi P, Mavilia L, Danesi A, Rossi R, Cappugi P. Monochromatic excimer light (308 nm): an immunohistochemical study of cutaneous T cells and apoptosisrelated molecules in psoriasis. J Eur Acad Dermatol Venereol 2003;17:408.

  10. Morelli JG, Kincannon J, Yohn JJ, Zekman T, Weston WL, Norris DA. Leukotrienes C4 and TNF-alpha are stimulators of human melanocyte migration in vitro. J Invest Dermatol 1992;98:290-5.

  11. Cheryl Guttman. Lasers safely target areas of limited psoriatic lesions. Dermatology Times. Jul 1, 2004.

  12. Spencer JM, Hadi SM. The excimer lasers. Drugs Dermatol 2004;3:522-5.

  13. Bonis B, Kemeny L, Dobozy A, Bor Z, Szabo G, Ignacz F. 308 nm UVB excimer laser for psoriasis. Lancet 1997;350:1522.

  14. Parrish JA, Jaenicke KF. Action spectrum for phototherapy of psoriasis. J Invest Dermatol 1981;76:359-62.

  15. Feldman SR, Mellen BG, Housman TS, Fitzpatrick RE, Geronemus RG, Friedman PM, Vasily DB et al. Efficacy of the 308-nm excimer laser for treatment of psoriasis: results of a multicenter study. J Am Acad Dermatol 2002;46: 900每6.

  16. Trehan M, Taylor CR. Medium-dose 308-nm excimer laser for the treatment of psoriasis. J Am Acad Dermatol 2002; 47:701每8.

  17. Asawanonda P., Anderson R.R., Chang Y., Taylor C.R. 308-nm excimer laser for the treatment of psoriasis: a dose response study. Arch Dermatol 2000;136:619-24.

  18. Aubin F, Vigan M, Puzenat E, Blanc D, Drobacheff C, Deprez P, Humbert P, Laurent R. Evaluation of a novel 308-nm monochromatic excimer light delivery system in dermatology: a pilot study in different chronic localized dermatoses Bri J Dermatol 2005;152:99每103.

  19. Campolmi P, Mavilia L, Lotti R, Rossi R, Brazzini B, Hercogova J, Capuggi P. 308nm monochromatic excimer light for the treatment of palmoplantar psoriasis. Int J Immunopathol Pharmacol 2002; 11:11每3.

  20. Kollner K, Wimmershoff MB, Hintz C, Landthaler M, Hohenleutner U. Comparison of the 308-nm excimer laser and a 308-nm excimer lamp with 311-nm narrowband ultraviolet B in the treatment of psoriasis. Br J Dermatol. 2005;152:750-4.

  21. Njoo MD, Westerhof W, Bos JD, Bossuyt PM. The development of guidelines for the treatment of vitiligo. Arch Dermatol 1999;135: 1514-21.

  22. Passeron T, Ostovari N, Zakaria W, Fontas E, Larrouy JC, Lacour JP, Ortonne JP. Topical Tacrolimus and the 308-nm Excimer Laser. A Synergistic Combination for the Treatment of Vitiligo. Arch Dermatol. 2004;140:1065-9.

  23. Gundogan C, Greve B, Raulin C. Treatment of alopecia areata with the 308-nm xenon chloride excimer laser: case report of two successful treatments with the excimer laser. Lasers Surg Med. 2004;34:86-90.

  24. Trehan M, Taylor CR. Low-dose excimer 308-nm laser for the treatment of oral lichen planus. Arch Dermatol. 2004;140:415-20.

  25. Duthie MS, Kimber I, Norval M. The effect of ultraviolet radiation on the immune system. Br J Dermatol 1999;140:995-1009.

  26. Guckian M, Jones CD, Vestey JP, Cooper EJ, Dawe R, Gibbs NK, Nor val M. Immunomodulation at the initiation of phototherapy and photochemotherapy. Photodermatol Photoimmunol Photomed 1995;11:163-9.

  27. Nistico S, Costanzo A, Saraceno R, Chimenti S. Effi cacy of monochromatic excimer laser radiation (308 nm) in the treatment of early stage mycosis fungoides. Br J Dermatol. 2004;151:877-9.

  28. Mori M, Campolmi P, Mavilia L, Rossi R, Cappugi P, Pimpinelli N. J Am Acad Dermatol. 2004;50:943-5.

  29. Warshaw E. N. Therapeutic options for chronic hand dermatitis. Dermatologic Therapy 2004,17:240每50.

  30. Rosen K, Mobacken H, Swanbeck G. Chronic eczematous dermatitis of the hands: a comparison of PUVA and UVB treatment. Acta Derm Venereol 1987; 67: 48每54.

  31. Simons JR, Bohnen IJ, van der Valk PG. A left每right comparison of UVB phototherapy and topical photochemotherapy in bilateral chronic hand dermatitis after 6 weeks treatment. Clin Exp Dermatol 1997;22: 7每10.

  32. Nordal EJ, Christensen OB. Treatment of chronic hand dermatoses with UVB-TL01. Acta Derm Venereol 2004;84:302-4.

  33. Ozawa M, Ferenczi K, Kikuchi T, Cardinale I, Austin LM, Coven TR, Burack LH et al. 312-nanometer ultraviolet B light (narrow-band UVB) induces apoptosis of T cells within psoriatic lesions. J Exp Med 1999;189: 711-8.

>Journals >Medicina Cut嫕ea Ibero-Latino-Americana >Year 2006, Issue 3

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