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CorSalud (Revista de Enfermedades Cardiovasculares)

ISSN 2078-7170 (Electronic)
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2019, Number 2

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CorSalud 2019; 11 (2)

Transient sinus dysfunction secondary to lacosamide treatment

Grados SD, Gracia GA, García AC, Toribio VB, León SE, Martínez HC, Reinoso R, Ruiz MF
Full text How to cite this article

Language: Spanish
References: 6
Page: 167-170
PDF size: 619.59 Kb.


Key words:

heart rhythm, sinus dysfunction, anticonvulsants, lacosamide, adverse effects.

ABSTRACT

The case of an 84-year-old female patient is presented, with a history of high blood pressure, dyslipidemia, chronic venous failure and osteoarthritis, which –due to trigeminal neuralgia– had received treatment with several drugs, without achieving neuropathic pain control; that was why the treatment with lacosamide was started in monotherapy, with an increase in dose until the therapeutic objective was achieved; but the patient presented clinical manifestations and electrocardiographic alterations compatible with sinus dysfunction, which were solved after reducing the dose of the drug.


REFERENCES

  1. Chinnasami S, Rathore C, Duncan JS. Sinus node dysfunction: An adverse effect of lacosamide. Epilepsia. 2013;54(6):e90-3. [ Links ]

  2. Vogler J, Breithardt G, Eckardt L. Bradiarritmias y bloqueos de la conducción. Rev Esp Cardiol. 2012;65(7):656-67. [ Links ]

  3. Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, et al. 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: The Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Eur Heart J. 2013;34(29):2281-329. [ Links ]

  4. Brignole M, Menozzi C, Moya A, Andresen D, Blanc JJ, Krahn AD, et al. Pacemaker therapy in patients with neurally mediated syncope and documented asystole: Third International Study on Syncope of Uncertain Etiology (ISSUE-3): a randomized trial. Circulation. 2012;125(21):2566-71. [ Links ]

  5. Tsuchioka Y, Yamaoka K, Hashimoto M, Yamamoto M, Sueda T, Matsuura H, et al. Electrophysiological effects of diphenylhydantoin in patients with sinus node dysfunction. Jpn Heart J. 1986;27(2):159-66. [ Links ]

  6. Kennebäck G, Bergfeldt L, Vallin H, Tomson T, Edhag O. Electrophysiologic effects and clinical hazards of carbamazepine treatment for neurologic disorders in patients with abnormalities of the cardiac conduction system. Am Heart J. 1991;121(5):1421-9. [ Links ]




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CorSalud. 2019;11