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2019, Number 2

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Revista de Ciencias Médicas de la Habana 2019; 26 (2)

Characterization of glycosylated hemoglobin A1c in healthy pregnancies

Arencibia FY, Piloto RI, Gonzáles PA, Bello FM

Language: Spanish
References: 18
Page: 135-144
PDF size: 486.27 Kb.


ABSTRACT

Introduction: in pregnant women with pregestational diabetes mellitus (type 1 or 2) and gestational diabetes the determination of glycosylated hemoglobin is particularly important because its correlational value has been seen with the development of maternal and fetal complications.
Objective: to characterize the glycosylated hemoglobin in the different trimesters of pregnancy.
Methods: cross-sectional analytical observational study in the Manuel Fajardo Gyneco-Obstetric Hospital during the second semester of 2016 to 100 healthy pregnancies that attended the prenatal control; and a control group of 150 healthy non-pregnant women older than 17 years in the population corresponding to the municipality of Güines who met the inclusion and exclusion criteria. Determinations of glycosylated hemoglobin and fasting glycemia were made.
Results: the healthy pregnant women the average glycosylated hemoglobin was lower than in non-pregnant women, respectively 4.50 % (4.41-4.49) versus 5.21 % (5.16-5.26), P <0.001. In the healthy pregnant group, glycosylated hemoglobin increased with the trimester of pregnancy p <0.05, first trimester: 4.35 (4.20 - 4.47), second trimester: 4.58 (4.45 - 4.70), third trimester: 4.61 (4.14 - 5.08).
Conclusions: during pregnancy the percentage of Hb A1c increases with the trimester of pregnancy, so it is important to determine its reference value for better metabolic control of pregnant women.


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