Souto-Rosillo MG, Bastida-González E, Vidal-Sánchez IE

Language: Spanish
References: 15
Page: 927-930
PDF size: 350.44 Kb.

ABSTRACT

Currently, procalcitonin, an acute phase reactant, has been considered a useful biomarker, not only in the diagnosis of bacterial infections and sepsis, but also to differentiate between these and other inflammatory and febrile syndromes. In this article, we review the current knowledge and its use in the clinical laboratory setting. According to the Third International Consensus Definitions for Sepsis and Septic Shock in 2016, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.

REFERENCES

1. Long S, Prober C. Principles and practice of pediatric infectious diseases. 5th ed. USA: Elsevier; 2018:1149-1450p.

2. Miedema KG, de Bont ES, Elferink RFO, van Vliet MJ, Nijhuis CSO, Kamps WA, Tissing WJ. The diagnostic value of CRP, IL- 8, PCT, and sTREM-1 in the detection of bacterial infections in pediatric oncology patients with febrile neutropenia, Support Care Cancer 2011;19(10):1593-160. doi: 10.1007/ s00520-010-0987-6.

3. Brechot N, Hekimian G, Chastre J, Luyt CE. Procalcitonin to guide antibiotic therapy in the ICU. Int J Antimicrob Agents 2015;46(Suppl 1):S19-24. doi: 10.1016/j.ijantimicag. 2015.10.012.

4. Schuetz P, Müeller B. Procalcitonin in critically ill patients: time to change guidelines and antibiotic use in practice. Lancet Infect Dis 2016;16(7):758-760. doi: 10.1016/S1473- 3099(16)00064-5.

5. Dandona P, Nix D, Wilson MF, Aljada A, Love J, Assicot M, et al. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994;79:1605-8. DOI: 10.1210/jcem.79.6.7989463.

6. Firestein G, Budd R, Gabriel S, McInnes I, O’Dell J. Tratado de reumatología. 10a ed. España: Elsevier; 2018:850p.

7. Fernández P. Procalcitonina: su utilidad como marcador de la sepsis. Disponible en: https://www.iaca.com.ar/images/ docs/Procalcitonina.pdf

8. Bonilla Diego A, Cuervo Sonia I, Gómez Julio C. Utilidad de la procalcitonina en pacientes adultos con neoplasias hematológicas y neutropenia febril posquimioterapia. Estado del arte. Asociación Colombiana de Infectología. Infectio 2012;16(4):223-229. DOI: 10.1016/S0123- 9392(12)70017-6.

9. Von Lilienfeld-Toal M, Dietrich MP, Glasmacher A, Lehmann L, Breig P, Hahn C, et al. Markers of bacteremia in febrile neutropenic patients with hematological malignancies: procalcitonin and IL-6 are more reliable than C-reactive protein. Eur J Clin Microbiol Infect Dis 2004;23:539-44. DOI: 10.1007/s10096-004-1156-y.

10. Kim MH, Lim G, Kang SY, Lee WI, Suh JT, Lee HJ. Utility of procalcitonin as an early diagnostic marker of bacteremia in patients with acute fever. Yonsei Med J 2011;52:276-81. doi: 10.3349/ymj.2011.52.2.276.

11. Dandona P, Nix D, Wilson MF, Aljada A, Love J, Assicot M, et al. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994;79:1605-8. DOI: 10.1210/jcem.79.6.7989463.

12. Barba JR. Procalcitonina: su papel como biomarcador de sepsis. Rev Mex Patol Clin 2008;55(3):157-167.

13. Remolina-Schlig M. Procalcitonina, marcador de inflamación sistémica. Fundación Clínica Médica Sur, México 2005;12(4) Octubre-Diciembre.

14. Memar M, Varshochi M, Shokouhi B, Asgharzadeh M, Kafil S. Procalcitonin: The marker of pediatric bacterial infection. Biomed Pharmacother 2017;936-943. doi: 10.1016/j. biopha.2017.11.149.

15. Chen DY, Chen YM, Lan JL, et al. Diagnostic value of procalcitonin for differentiation between bacterial infection and non-infectious inflammation in febrile patients with active adult-onset Still’s disease. Ann Rheum Dis 2009;68:1074-5. doi: 10.1136/ard.2008.098335.