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Anales de Otorrinolaringología Mexicana

2019, Number 4

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Otorrinolaringología 2019; 64 (4)

Clinical correlation and levels of urinary LTE4 with a high and low salicylate diet in patients with aspirin-exacerbated respiratory disease

Palacios-Solís EL, Jiménez-Chobillon MA, Castorena-Maldonado AR, García-Cruz ML, Gamiño-Pérez A

Language: Spanish
References: 25
Page: 188-201
PDF size: 537.30 Kb.


ABSTRACT

Background: Aspirin exacerbated respiratory disease is characterized by asthma, chronic rhinosinusitis, nasal polyposis, and hypersensitivity to aspirin. There are studies that have shown that salicylic acid in foods can have systemic effects similar to those produced by acetylsalicylic acid.
Objective: To compare urinary leukotriene E4 (LTE4u) levels in patients with aspirin exacerbated respiratory disease after low and high salicylate diet.
Material and Method: A study including patients with aspirin exacerbated respiratory disease and healthy controls was done between 2017 and 2018. During the first internment they received a low salicylate diet, a baseline measurement of spirometry, rhinomanometry and measurement of LTE4u was made and these measurements were repeated two hours after breakfast, lunch and dinner. In the second hospitalization they received a diet high in salicylates, making the same measurements in the established schedules.
Results: There were included 9 patients and 8 controls. An ANOVA model of repeated measures was performed comparing each diet with a statistically significant result (p = 0.0001). The leukotrienes changed throughout the 8 measurements and it was significant for both groups (p = 0.0002). However, between controls and aspirin exacerbated respiratory disease there was no significant difference (p = 0.341).
Conclusions: There is an elevation of LTE4u after the intake of a diet high in salicylates. A diet low in salicylates could have a clinical utility in a subgroup of patients with aspirin exacerbated respiratory disease and greater sensitivity to salicylates in the diet.


REFERENCES

  1. Rabinovitch N. Urinary leukotriene E4 as a biomarker of exposure, susceptibility and risk in asthma. Immunol Allergy Clin North Am 2012;32:433-445. doi: 10.1016/j. iac.2018.06.011.

  2. Bochenek G, Nizankowska-Mogilnicka E. Aspirin-Exacerbated Respiratory Disease: Clinical Disease and Diagnosis. Am Immunol Allergy Clin N 2013;33:147-161. doi: 10.1016/j. iac.2012.10.002.

  3. Lee R, Stevenson D. Aspirin-exacerbated respiratory disease: evaluation and management. Allergy Asthma Immunol Res 2011;3:3-10. https://dx.doi. org/10.4168%2Faair.2011.3.1.3

  4. Mitchell J, et al. Aspirin and salicylate in respiratory disease. Rhinology 2013;51:195-205. doi: 10.4193/Rhino12.144.

  5. Dahlin A, et al. Genetic and epigenetic components of aspirin-exacerbated respiratory disease. Immunol Allergy Clin North Am 2016;36:765-789. doi: 10.1016/j. iac.2016.06.010.

  6. Laidlaw T, Boyce J. Pathogenesis of aspirin-exacerbated respiratory disease and reactions. Am Immunol Allergy Clin N 2013;33:195-210. doi: 10.1016/j.iac.2012.11.006

  7. Higashi N, et al. Aspirin-intolerant asthma (AIA) assessment using the urinary biomarkers, leukotriene E₄ (LTE₄) and prostaglandin D₂ (PGD₂) metabolites. Allergol Int 2012;61:393- 403. doi: 10.2332/allergolint.11-RA-0403.

  8. Murphy RC, et al. Biosynthesis and metabolism of leukotrienes. Biochem J 2007;405:379-395. DOI: 10.1042/ BJ20070289

  9. Rabinovitch N. Urinary leukotriene E4. Immunol Allergy Clin North Am 2007;27:651-664. DOI: 10.1016/j. iac.2007.09.004

  10. Celejewska WN, et al. Incidence of aspirin hypersensitivity in patients with chronic rhinosinusitis and diagnostic value of urinary leukotriene E4. Pol Arch Med Wewn 2012;122(9):422-7.

  11. Sommer D, et al. Treatment of aspirin exacerbated respiratory disease with a low salicylate diet: a pilot crossover study. Otolaryngol Head Neck Surg 2015;152(1):42-47. doi: 10.1177/0194599814555836.

  12. Szefler S, et al. Asthma outcomes: Biomarkers. J Allergy Clin Immunol 2012 Mar; 129(3 Suppl):S9-S23. https://dx.doi. org/10.1016%2Fj.jaci.2011.12.979

  13. Kumlin M. Measurement of leukotrienes in humans. Am J Respir Crit Care Med 2000;161(2):S102-6. https://doi. org/10.1164/ajrccm.161.supplement_1.ltta-20.

  14. Austen F, et al. The leukotriene E₄ puzzle: finding the missing pieces and revealing the pathobiologic implications. J Allergy Clin Immunol 2009;124(3):406-414. http://dx.doi. org/10.1016/j.jaci.2009.05.046

  15. Divekar R, et al. Diagnostic utility of urinary LTE₄ in asthma, allergic rhinitis, chronic rhinosinusitis, nasal polyps, and aspirin sensitivity. J Allergy Clin Inmunol Pract 2016 Jul- Aug;4(4):665-70. doi: 10.1016/j.jaip.2016.03.004.

  16. Paterson JR, et al. Salicylic acid content of spices and its implications. J Agric Food Chem 2006;54:2891-2896. DOI: 10.1021/jf058158w

  17. Janssen K, et al. Acetylsalicylate and salicylates in foods. Cancer Lett 1997;114:163-164. DOI: 10.1016/s0304- 3835(97)04650-8

  18. Duthie G, Wood D. Natural salicylates: foods, functions and disease prevention. Food Funct 2011;2:515-520. doi: 10.1039/c1fo10128e.

  19. Skypala I, et al. Sensitivity to food additives, vaso-active amines and salicylates: a review of the evidence. Clin Transl Allergy 2015;5:34. doi: 10.1186/s13601-015-0078-3

  20. Wood A, et al. A systematic review of salicylates in food: estimated daily intake of a Scottish population. Mol Nutr Food Res 2011;(Suppl 1):S7-S14. DOI: 10.1002/mnfr.201000408

  21. Sommer D, et al. A novel treatment adjunct for aspirin exacerbated respiratory disease: the low-salicylate diet: a multicenter randomized control crossover trial. Int Fo- rum Allergy Rhinol 2016 Apr;6(4):385-91. doi: 10.1002/ alr.21678.

  22. Smith CM, et al. Urinary leukotriene E₄ in bronchial asthma. Eur Respir J 1992;5(6):693-9.

  23. Micheletto C, et al. Changes in urinary LTE4 and nasal functions following nasal provocation test with ASA in ASAtolerant and intolerant asthmatics. Respiratory Medicine 2006;100:2144-2150. DOI: 10.1016/j.rmed.2006.03.017

  24. Esmaelizedeh H, et al. Salicylate food intolerance and aspirin hypersensitivity in nasal polyposis. Iran J Immunol. 2017 Mar;14(1):81-88. doi: IJIv14i1A8.

  25. Hagan JB, et al. Urinary leukotriene E₄ to determine aspirin intolerance in asthma: a systematic review and meta-analysis. J Allergy Clin Immunol Pract 2017 Jul-Aug;5(4):990-997. e1. doi: 10.1016/j.jaip.2016.11.004.




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