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Revista Médica Sinergia

2020, Number 01

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Revista Médica Sinergia 2020; 5 (01)

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis, a diagnostic and therapeutic challenge

Salazar MJ, Valverde JA, Agüero SAC

Language: Spanish
References: 16
Page: 308
PDF size: 161.61 Kb.


ABSTRACT

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis are severe mucocutaneous diseases with high morbidity and mortality. They are part of a spectrum of severe adverse cutaneous drug reactions, differing only by their extent of skin detachment. Medications are the main trigger usually at the beggining of treatment. The agents commonly involved may vary according to the population and their genetic differences. The pathophysiological mechanisms involved are not fully clarified, however the participation of granulisin, the Fas signaling pathway and inflammatory cytokines has been demonstrated. Patients with Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis are at high risk of developing bacterial infections that could lead to sepsis and other complications. The diagnosis requires a clinical-histopathological correlation and its management is mainly based on the suspension of the causative agent and the early aggressive supportive care. There is evidence that suggests the beneficts of immunomodulatory systemic therapies, but further evaluation in prospective studies is required.


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