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2019, Number 3

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Rev Cub Med Int Emerg 2019; 18 (3)

Hypoalbuminemia in children with severe pneumonia acquired in the community

Álvarez AME, Sánchez PLM, Carpio MMÁ, Pérez SM, Cuevas ÁD

Language: Spanish
References: 24
Page: 1-13
PDF size: 306.83 Kb.


ABSTRACT

Introduction: Hypoalbuminemia has been studied in seriously ill patients and has been considered as a predisposing factor in the evolution of children with severe community-acquired pneumonia.
Objective: To determine the relationship of hypoalbuminemia with biological, epidemiological and blood variables in children with severe community-acquired pneumonia.
Methods: An analytical, longitudinal investigation was carried out with 142 children suffering from severe community-acquired pneumonia, admitted to the Pediatric Intensive Care Unit at Dr. Ángel Arturo Aballí for Mother and Child Hospital, in Havana, from January 2014 to March 2018. The variables analyzed were age, serum albumin, malnutrition, previous days of evolution, complications, stay, leukocyte count, neutrophil count, sedimentation rate and C - reactive protein. The mean was calculated in the quantitative variables, and the simple association between the variables.
Results: There was a predominance of age group from 1 to 4 years (69.7%). Only 17.8% of the patients were malnourished. The disease prior to admission higher than or equal to five days was associated with hypoalbuminemia (p= 0.005 OR= 2.6), it similarly occurred with complications (p= 0.0001 OR= 4.5) and the hospital stay of seven or more days (p= 0.001 OR= 3.1). The absolute neutrophil count was higher than 10 655 (p= 0.003 OR= 2.8) and the C-Reactive Protein was positive (p= 0.006 OR= 2.9), both cases were related to decreased serum albumin values.
Conclusions: The analysis of hypoalbuminemia was useful, mainly, due to the relationship with the time of evolution of the disease prior to admission, the hospital stay and the presence of complications.


REFERENCES

  1. Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al Child Health Epidemiology Reference Group of WHO and UNICEF. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012 [citado: 12/10/2018];379(9832):2151-61. Disponible en: http://doi:10.1016/S0140-6736(12)60560-1

  2. Mosleh H, Labib JR. Accuracy of Risk Assessment Tool in Predicting Pneumonia’s Outcome among Egyptian Children: Hospital Based Study. BJM Med Research. 2013 [citado: 12/10/2018];3(4):2276-87. Disponible en: http://www.journalrepository.org/media/journals/BJMMR_12/2013/Sep/Mosleh342013BJMMR4965.pdf

  3. Pons Leite H, Rodrigues da Silva AV, de Oliveira Iglesias SB, Koch Nogueira PC. Serum Albumin Is an Independent Predictor of Clinical Outcomes in Critically Ill Children. Pediatr Crit Care Med. 2016 [citado: 27/06/2018];17(2):e50-7. Disponible en: http://doi.10.1097/PCC.0000000000000596

  4. Siguenza T, Webster E, Martínez F, Córdova F. Estudio Transversal: Neumonía Adquirida en la Comunidad en Niños. Rev Med HJCA. 2016 [citado: 12/10/2018];8(1):25-9. Disponible en: http://doi.org/10.14410/2016.8.1.ao.04

  5. Velázquez-Meza M, Dautt-Leyva J, Murillo-Llanes J, Tracy-Gastélum C. Hipoalbuminemia como factor relacionado a mortalidad en pacientes con sepsis del Hospital General de Culiacán. Arch Salud Sin. 2013 [citado: 27/06/2018];7(1). Disponible en: http://imbiomed.com.mx/1/1/articulos.php?method=showDetail&id_articulo=96370&id_seccion=2998&id_ejemplar=9417&id_revista=178

  6. Tiwari LK, Singhi S, Jayashree M, Baranwal AK, Bansal A. Hypoalbuminemia in critically sick children. Indian J Crit Care. 2014 [citado: 27/06/2018];18(9):565-9. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/25249740

  7. Fischbach FT, Dunning MB. Blood studies. Hematology and Coagulation. In: A Manual of Laboratory and Diagnostic Test. 8th ed. Philadelphia: Linppincott William-Wilkins; 2009. p. 56-183.

  8. Rodríguez Cutting JM, Calero Galeas AE, Vega Mendoza D, Pacheco Torres L. Neumonía complicada adquirida en la comunidad: Resolución de los hallazgos clínicos y radiológicos en niños. Rev Haban Cienc Méd. 2015 [citado: 12/09/2018];14(4):438-46. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1729-519X2015000400007

  9. Comité de Infecciones Respiratorias de la Sociedad Latinoamericana de Infectología Pediátrica. Consenso de la Sociedad Latinoamericana de Infectología Pediátrica (SLIPE) sobre Neumonía Adquirida en la Comunidad (NAC). Rev Soc Bol Ped. 2010 [citado: 22/10/2018];49(3):155-209. Disponible en: http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1024-06752010000300004&lng=es

  10. Moschovis PP, Addo-Yobo EO, Banajeh S, Chisaka N, Christiani DC, Hayden D. Stunting is associated with poor outcomes in childhood pneumonia. Trop Med Int Health. 2015 [citado: 27/09/2018];20(10):1320-8. Disponible en: http://doi: 10.1111/tmi.12557

  11. Montejo JC, Culebras JM, García MA. Recomendaciones para la valoración nutricional del paciente crítico. Rev Méd Chile. 2006 [citado: 27/06/2018];134:1049-56. Disponible en: http://dx.doi.org/10.4067/S0034-98872006000800016

  12. Barbosa MC. Subjective and objective nutritional assessment methods: what do they really assess? Curr Opin Nutr Metab Care. 2008 [citado: 27/09/2018];11:248-54. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/18403920

  13. Tamayo Reus CM, Bastart Ortiz EA, Cunill Romero S. Mortalidad por neumonía en menores de 5 años. MEDISAN. 2014 Mar [citado: 22/10/2018];18(3):327-33. Disponible en: http://scielo.sld.cu/pdf/san/v18n3/san05314pdf

  14. Álvarez Andrade ME, Cuevas Álvarez D. Valor de la albúmina sérica en niños admitidos en una unidad de cuidados intensivos. Rev Cub Med Int Emerg. 2015 [citado: 11/08/2018];14(4). Disponible en: http://www.revmie.sld.cu/index.php/mie/article/view/113/html_29

  15. Moreno-Pérez D, Martín AA, Tagarro-García A, Escribano-Montaner A, Figuerola-Mulet J, García-García JJ, et al. Neumonía adquirida en la comunidad: tratamiento ambulatorio y prevención. An Pediatr (Barc). 2015 [citado: 11/08/2018];83(6):439. Disponible en: http://www.enfermeriaaps.com/portal/wp-content/uploads/2016/09/Neumon%C3%ADa-adquirida-en-la-comunidad-tratamiento.pdf

  16. Bocanegra IE, Garza AG, Rodríguez I, Abrego V, Maltos W. Valor pronóstico de la hipoalbuminemia en niños en estado crítico. Rev Mex Pediatr. 2009 Mar [citado: 22/10/2018];76(3):117-20. Disponible en: http://www.medigraphic.com/pdfs/pediat/sp-2009/ sp093c.pdf

  17. Prais D, Kuzmenko E, Amir J, Harel L. Association of hypoalbuminemia with the presence and size of pleural effusion in children with pneumonia. Pediatrics. 2008 Mar [citado: 12/10/2018];121(3):533-8. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/18310174

  18. Viasus D, García-Vidal C, Simonetti A, Manresa F, Dorca J, Gudiol F, et al. Prognostic value of serum albumin levels in hospitalized adults with community-acquired pneumonia. J Infection. 2013 [citado: 23/03/2018];66(5):415-23. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/23286966.

  19. Martín A, Moreno-Pérez D, Couceiro Gianzo M, García García J, Korta Murua MI, Martínez León C, et al. Etiología y diagnóstico de la neumonía adquirida en la comunidad y sus formas complicadas. An Pediatr (Barc). 2012 [citado: 23/03/2018];76(3):162.e1-162.e18. Disponible en: https://www.sciencedirect.com/science/article/pii/S1695403311004875

  20. Sánchez-Villares L, Fernández Luis S, Serrano Ayestarán O, Sánchez Granados JM. Neumonías adquiridas en la comunidad en el Hospital Universitario de Salamanca. Bol Pediatr. 2015 [citado: 23/03/2018];55:25-31. Disponible en: https://www.sccalp.org/documents/0000/ 2153/BolPediatr2015_55_25_31.pdf

  21. Flores Nava G, Martínez García IM, Hernández Delgado L, Delgado Fernández A. Alteraciones en la cuenta de leucocitos en un grupo de niños hospitalizados por neumonía de la comunidad. Rev Pediatr México. 2011 [citado: 12/10/2018];13(3):92-5. Disponible en: http://www. medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=31699

  22. Flood RG, Badik J, Aronoff SC. The Utility of Serum C-Reactive Protein in Differentiating bacterial from non-bactrial pneumonia in Children. A Meta-Analysis of 1230 Children. Pediatr. Infect. Dis J. 2008 [citado: 27/09/2018];27(2):95-9. Disponible en: https://www.ncbi. nlm.nih.gov/pubmed/18174874

  23. Sun JK, Sun F, Wang X, Yuan ST, Zheng SY, Mu XW. Risk factors and prognosis of hypoalbuminemia in surgical septic patients. Peer J. 2015 [citado: 12/10/2018];3:1267. Disponible en: https://doi.org/10.7717/peerj.1267

  24. Villar-Centeno LA, Lozano-Parra A, Salgado-García D, Herrán OF. Alteraciones como marcadores predictores de gravedad en pacientes con fiebre por dengue. Rev Biomédica. 2013 [citado: 23/03/2018];33(1):63-9. Disponible en: http://dx.doi.org/10.7705/biomedica.v33i0.732




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