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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2020, Number 1

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Rev Biomed 2020; 31 (1)

Insulin resistance related with biochemical and anthropometric alterations in adolescents with prediabetes

Ceballos-Pomares JC, Solís-Martínez RA, Quevedo-Carreño A, López-Muñoz MJJD, Moreno-Cortés ML

Language: Spanish
References: 28
Page: 22-27
PDF size: 284.05 Kb.


ABSTRACT

Introduction. Prediabetes (PD) is characterized by a decrease in insulin sensitivity or insulin resistance (IR) and hyperinsulinemia; however, and unlike type 2 diabetes (T2D), if detected in a timely manner, PD can be reversed. Therefore, the timely detection of IR, as a characteristic of PD represents a window of opportunity to prevent the progression of up to 10% of cases.
Objective. To detect in a timely manner cases of IR in young and identify if this is associated with biochemical and anthropometric variables.
Materials and methods. Cross-sectional study of 131 adolescents, distributed according to their glucose level in: normo-glycemic group (NG, n = 67) and prediabetic group (PD, n = 64); insulin, glucose, total cholesterol and triglycerides levels were determined. The IR was identified by the HOMA index. Overweight or obesity were established by the body mass index (BMI) and waist-height index (IC/T), in addition to the fat mass percentage.
Results. The subjects presented IR, in addition to a tendency of insulin levels and BMI increment; total cholesterol and triglycerides remain in the normal range. Correlation of BMI, IC/T and triglycerides was observed with the HOMA index in the PD group.
Conclusion. The adolescents between 18 and 20 years old have IR even when there are no alterations of lipids in blood or body weight.


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