Gómez-Pérez D, Meijides-Mejías C, Dorta-Contreras AJ

Language: English
References: 7
Page: 1-8
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ABSTRACT

Introduction: Angiostrongylus cantonensis is a zoonotic pathogen that causes human angiostrongyliasis; its main clinical manifestation is eosinophilic meningitis. It was reported in Cuba for the first time in America.
Objective: To review the main immunological findings about the human neuroimmune response against this parasite.
Methods: This paper is based on a review of the papers mainly from Cuban authors published in the last 10 years about the human neuroimmune response against this helmint. This information becomes more relevant after the introduction of the African giant snail Lissachatina fulica in Cuba in 2014.
Results: The humoral immune response is based on the immunoglobulin intrathecal synthesis. When the third-stage larvae go to the central nervous system at the first lumbar puncture there are no major immunoglobulin synthesis. One week later an immune intrathecal response is done by a two-class major immunoglobulin class mainly IgG+ IgA Intrathecal activation of complement is evident of intrathecal synthesis of major immunoglobulins during this disease. The activation of complement system components in cerebrospinal fluid is relevant to the understanding of this tropical disease, which is emerging in the Western hemisphere. Intrathecal synthesis of at least one of the major immunoglobulins and a wide spectrum of patterns may be observed. Although intrathecal synthesis of C3c and IgE is always present, C4 intrathecal synthesis does not occur in every patient. The diversity of intrathecal synthesis and activation of the different complement pathways enables their division into three variant groups. In each one could be finding the activation of one or several complement pathways including the participation of MBL, MASP-2 and ficolins as part of the lectin pathway complement activation.
Conclusion: The neuroimmune response against Angiostrongylus cantonensis eosinophilic meningoencephalitis is an example of the host-parasite interaction.

REFERENCES

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2. Padilla-Docal B, Dorta-Contreras AJ, Bu-Coifiu-Fanego R, Fundora-Hernandez H, Callol-Barroso J, Sanchez-Martinez C. Intrathecal synthesis of IgE in children with eosinophilic meningoencephalitiscaused by Angiostrongylus cantonensis. Cerebrospinal Fluid Res. 2008;5(1):18 disponible en: http://www.cerebrospinalfluidresearch.com/content/5/1/18 .

3. Padilla-Docal B, Dorta-Contreras AJ, Bu-Coifiu-Fanego R. Activación y biosíntesis intratecal de C3c en niños con meningoencefalitis eosinofílica por Angiostrongylus cantonensis.Rev Neurol. 2009;48:632-5.

4. Padilla-Docal B, Dorta-Contreras AJ, Bu-Coifiu-Fanego R, Rodríguez-Rey A, Gutiérrez-Hernández JC, de Paula-Almeida SO. Reibergram of intrathecal synthesis of C4 in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. Am J Trop Med Hyg 2010; 82(6):1094-8.

5. Padilla-Docal B, Iglesias-Gonzalez I, Bu-Coifiu-Fanego R, Socarras-Hernandez CA, Dorta-Contreras AJ. Intrathecal. Activation as a Typical Immune Response within the Central Nervous System in Angiostrongyliasis Am. J. Trop. Med. Hyg.2013;88(2);230-235.

6. Dorta-Contreras A. Deficiencia de manosa unida a lectina (MBL) en niños con meningoencefalitis por Angiostrongylus cantonensis. Una serie de casos. Revista Cubana de Hematología, Inmunología y Hemoterapia [revista en Internet]. [citado 2018 Ago 1];33(S1):[aprox. 4 p.]. Disponible en: http://www.revhematologia.sld.cu/index.php/hih/article/view/799 .

7. González-Losada C, Padrón-González AA, Lumpuy-Castillo J, Rodriguez-Pérez A, Castillo-González W, Dorta-Contreras AJ. Intrathecal Activation of the Lectin Pathway in Patients with Eosinophilic Meningitis by Angiostrongylus cantonensis. FASEB J 2018;32, 1_supplement: 741.2. Disponible en: https://www.fasebj.org/toc/fasebj/32/1_supplement , Abstract 741.2 ;Consultado Abril 22, 2018.