Padrón-González AA, Lumpuy-Castillo J, Rodríguez-Pérez JA, Pérez-Vallín V, Mirabal-Viel A, Castillo-González W, Dorta-Contreras AJ

Language: English
References: 10
Page: 1-7
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ABSTRACT

Introduction: Quincke´s Scholarship deals with themes related to neuroinmunology and the complement system.
Objective: Describe the most recent advances of the Vll Edition of Quincke´s Scholarship.
Methods: Publications pertaining to Quincke´s Scholarship were selected and revised from the work group of the Central Lab of Cerebrospinal fluid (LABCEL).
Results: The principal topic was the C1q protein; initiator of the clasic complement pathway. From the analisis of the molecular concentration of this protein, its transference and the correlations between the concentration of C1q protein in cerebrospinal fluid (LCR) and the quotient of albumin (QAlb) between LCR and plasma it is hypothesized that an intratecal synthesis of the C1q in patients with a disfunction of the blood-brain barrier.
The most recently discovered pathway in the activation of the complement is the lectin pathway. The diffusion of the MASP-3 protein from blood to LCR is proof that the MASP-3 is synthesized in the leptomeninges.
The reibergram is useful to evaluate the inmune response in patients with: neurological manifestations caused by the dengue virus, and patients with multiple sclerosis.
Conclusions: The Vll Edition of Quincke´s Scholarship dealt with C1q protein and recently discovered themes of the lectin pathway and the use of the reibergram.

REFERENCES

1. Padrón-González AA, Dorta-Contreras AJ, Rodríguez-Pérez JA, Castillo González, González-Losada C. Becas Quincke: siete años multiplicando la experiencia. Inmunología [Internet]. 2018 [consultado 23 Abr 2019];37(4):46-49. Disponible en: https://issuu.com/seinmunologia/docs/sei-v37-n4-2018

2. Lumpuy-Castillo J, Jiménez-Hernández E, González-Losada C, Rodríguez-Pérez JA and Dorta-Contreras AJ. Teaching immunology based on open science´s principles. Conference Abstract: XII Congress of the Latin American Association of Immunology & XXIII Congress of the Mexican Society of Immunology.

3. Lumpuy-Castillo J, González-Losada C, Schmitz M, Gudmann Hansen A, Jensenius JC, Dorta-Contreras AJ.C1q Intrathecal Synthesis in Patients Without Inflammatory Diseases with Blood-Brain Dysfunction. FASEB J 2018[Consultado Agosto 22, 2018]; 32, 1_supplement: 741.3. Disponible en: https://www.fasebj.org/toc/fasebj/32/1_supplement

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5. Padrón-González A, Dorta-Contreras J. Vía de las lectinas, una ruta del complemento en construcción. Archivos de alergia e inmunología clínica. [Internet]. 2018. [citado 28 Ago 2018]. (1):5-12. Disponible en: http://www.archivos.org.ar/contenido/art.php?recordID=MTA5MQ

6. Rodriguez-Pérez JA, Pérez-Vallín V, Mirabal-Viel A, Padrón-González AA, Castillo- González W, González-Losada C, Dorta-Contreras AJ. Epstein Barr Virus and Multiple Sclerosis. FASEB J 2018[Consultado Agosto 22, 2018]; 32, 1_supplement: 617.3. Disponible en: https://www.fasebj.org/toc/fasebj/32/1_supplement

7. González-Losada C, Padrón-González AA, Lumpuy-Castillo J, Rodriguez-Pérez A, Castillo-González W, Dorta-Contreras AJ. Intrathecal Activation of the Lectin Pathway in Patients with Eosinophilic Meningitis by Angiostrongylus cantonensis. FASEB J 2018; 32, 1_supplement: 741.2. Disponible en: https://www.fasebj.org/toc/fasebj/32/1_supplement , Abstract 741.2 ;Consultado Abril 22, 2018.

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9. Dorta-Contreras A J, Padrón-González A A, González-Losada C, Lumpuy-Castillo J, Rodriguez-Pérez J A, Ramos-Robledo A, Martínez-Reyes J, et al. MASP-3: a new leptomeningeal protein in the lectin pathway. The FASEB Journal 2018 32:1_supplement, 741.5-741.5

10. Padrón-González A A, González-Losada C, Lumpuy-Castillo J, Rodriguez-Pérez J A, Ramos-Robledo A, Castillo-González W, Dorta-Contreras A J. MASP-3 aggregation and its blood to cerebrospinal fluid diffusion. The FASEB Journal 2018 32:1_supplement, 741.1-741.1