2019, Number 1
Melatonin and its neuroimmunological actions
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Language: English
References: 9
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ABSTRACT
Introduction: Melatonin is a neurohormone, synthesized mainly in the pineal gland, which regulates the circadian rhythm.Objective: To describe the neuroimmunological actions produced by melatonin.
Methods: A review on the subject was carried out using articles of free access in the Pubmed database from 2015 to January 2019.
Discussion: The effects of melatonin on the wake-sleep cycle are known. Recently it has been shown that this neurohormone can modulate the immune response and reduce seizures in autoimmune and rheumatologic diseases. It induces the pattern of regulatory T lymphocytes and immunomodulatory cytokines maintaining the homeostasis of the internal environment. In the Central Nervous System inhibits the formation of free radicals, has antioxidant functions and can slow neurodegenerative processes. In the peripheral nerves decreases oxidative stress and cellular apoptosis. There are drugs that use melatonin as an active ingredient for its beneficial effects. In Cuba, only the history of a publication on this hormone is collected.
Conclusions: Melatonin can be a very useful element in the management of inflammatory and neurological diseases.
REFERENCES
Ferreira CS, Carvalho KC, Maganhin CC, Paiotti APR, Oshima CTF, Simões MJ et al. Does melatonin influence the apoptosis in rat uterus of animals exposed to continuous light? Apoptosis [Internet]. 2016 [consultado 15 Feb 2019];21(2):155-162. Disponible en: https://link.springer.com/article/10.1007%2Fs10495-015-1195-0
Jiunn-Diann L, Shun-Fa Y, Yuan-Hung W, Wen-Fang F, Ying-Chin L, Bing-Chun L, et al. Associations of melatonin receptor gene polymorphisms with Graves' disease.PLoS One [Internet]. 2017[consultado 15 Mar 2019];12(9): e0185529. Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185529
Padrón-González AA, Martínez-Infante A. Estrés, Psiconeuroendocrinoinmunología y enfermedades reumatológicas. Actualización del tema. Rev Cuba Reumatol [Internet]. 2018 Dec [cited 2018 Dec 07]; 20(3): e628. Available from: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1817- 59962018000300012&lng=en .