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Revista Cubana de Investigaciones Biomédicas

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2019, Number 1

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Rev Cubana Invest Bioméd 2019; 38 (1)

Hormones, food, stress and infections: their etiological role in autoimmune diseases

Rodríguez MA, González-Costa M, Padrón-González AA
Full text How to cite this article

Language: English
References: 10
Page: 1-6
PDF size: 110.70 Kb.


Key words:

autoimmunity, hormones-autoimmunity, stress-autoimmunity, foodautoimmunity, infections-autoimmunity.

ABSTRACT

Introduction: The etiology of autoimmune diseases is still unknown, but different causes arise.
Objective: To describe the role of hormones, diet, stress and infections in the etiology of autoimmune diseases.
Methods: A bibliographic review was made using the Google Scholar and articles of free access in the Pubmed and Scielo database from 2015 to 2019. The search terms were used according to the DeCS and MeSH descriptors.
Development: It is well known that female hormones increase the risk of autoimmune diseases. Stress can maintain low-grade chronic inflammatory responses that cause tissue damage, initiating or aggravating the clinical manifestations of autoimmunity. An adequate diet allows the guests of the intestinal microbiota to maintain the homeostasis of the immune system. Today, glutamate is used as a flavor enhancer, especially in developed countries. Perhaps it is one of the causes of the higher incidence of autoimmune diseases in these regions.
Conclusions: Autoimmune diseases are more frequent in women. Adequate nutrition allows the gut microbiota not to be altered and to maintain immunological homeostasis. Infections and stress situations can trigger or exacerbate the clinical manifestations of autoimmunity.


REFERENCES

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  2. Xu Y, Chen G. Mast Cell and Autoimmune Diseases.MediatorsInflamm. [Internet]. 2015[consultado 8 Jul 2018];2015(2015):246126. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402170/

  3. González-Costa M, Padrón González AA. La inflamación desde una perspectiva inmunológica: desafío a la Medicina en el siglo XXl. Rev haban cienc méd [Internet]. 2018 [consultado2019 Mar 01]; 18(1):30-44. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445

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  6. Rodriguez-Pérez JA, Pérez-Vallín V, Mirabal-Viel A, Padrón-González AA, Castillo- González W, González-Losada C, Dorta-Contreras AJ. Epstein Barr Virus and Multiple Sclerosis. FASEB J [Internet]. 2018 [consultado 19Abr 2019]; 32 (Suppl1): 617.3. Disponible en: https://www.fasebj.org/toc/fasebj/32/1_supplement

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  9. Padrón-González AA, González-Costa M. Glutamato, eje hipotálamo-hipófiso-adrenal y manifestaciones clínicas en la esclerosis múltiple. RevNeurol [revista en Internet]. 2019 [consultado4 Feb 2019]; 68: 134. Disponible en: https://www.neurologia.com/articulo/2018479

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Rev Cubana Invest Bioméd. 2019;38