2019, Number 2
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Rev Cubana Med Trop 2019; 71 (2)
Antimicrobial peptides in multiresistant respiratory infections
González-García M, Ständker L, Otero-González AJ
Language: English
References: 49
Page: 1-16
PDF size: 263.15 Kb.
ABSTRACT
Antimicrobial peptides are small cationic molecules present in almost all living organisms.
They show direct or indirect (immunomodulation) activity in a wide range of pathogenic
microorganisms as members of the humoral arsenal of innate immunity. In mammals they
play a significant role in respiratory airways. The most abundant antimicrobial peptides in
the respiratory tract of mammals are lysozymes, lactoferrin, histatins, defensins and
cathelicidins. Respiratory and pulmonary infections are combated, primarily, by
antimicrobial peptides like LL-37 against Gram-negative bacteria, histatin 5 against Candida
albicans and human peptides from neutrophils against adenovirus, influenza and
parainfluenza. This paper provides a review of the most important antimicrobial peptides in
the respiratory tract and their use in the search for new effective agents against
microorganisms that cause respiratory infections based on information published in
MedLine, the Web of Science and Scopus in recent years.
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