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2006, Number S2

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Rev Med Inst Mex Seguro Soc 2006; 44 (S2)

Artificial blood and plasma expanders: the future of transfusion

Salazar VBY, Martini J, Cabrales P, Intaglietta M
Full text How to cite this article

Language: Spanish
References: 7
Page: 129-132
PDF size: 67.57 Kb.


Key words:

Transfusion, plasma expanders, viscosity, microcirculation, red blood cells.

ABSTRACT

Transfusion of red blood cells is performed to re-establish oxygen-carrying capacity; however, this intervention can be delayed and made at significantly lower hemoglobin levels than those conventionally considered if microvascular function is maintained by means of high viscosity plasma expanders. Albumin combined with polyethylene glycol and alginates has been found to be effective in maintaining capillary function in extreme hemodilution and hemorrhagic shock.


REFERENCES

  1. Wettstein R, Tsai AG, Erni D, Lukyanov AN, TorchilinVP, Intaglietta. M. Improving microcirculation is more effective than substitution of red blood cells to correct metabolic disorder in experimental hemorrhagic shock. Shock 2004;21:235-240.

  2. R. Argüero-Sánchez. Hemodilución en medicina y cirugía. México, DF: JGH Editores; 2000. p. 69-79.

  3. Messmer K. Hemodilution. Surg Clins N Am 1975;55:659-678.

  4. Cabrales P, Tsai AG, Intaglietta M. Microvascular pressure and functional capillary density in extreme hemodilution with low-and highviscosity dextran and a low-viscosity Hb-based O2 carrier. Am J Physiol Heart Circ Physiol 2004;287:H363-H373.

  5. Cabrales P, Tsai AG, Winslow RM, Intaglietta M. Extreme hemodilution with Peg-hemoglobin vs. Peg-albumin. Am J Physiol Heart Circ Physiol 2005;289:H2392-H2400.

  6. Cabrales P, Tsai AG, Intaglietta M. Hyperosmotichyperoncotic vs hyperosmotic-hyperviscous small volume resuscitation in hemorrhagic shock. Shock 2004;22:431-437.

  7. Tsai AG, Acero C, Nance PR, Cabrales P, Frangos JA, Buerk DG, Intaglietta M. Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion. Am J Physiol Heart Circ Physiol 2005;288:H1730-H1739.




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Rev Med Inst Mex Seguro Soc. 2006;44