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2020, Number 1

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Finlay 2020; 10 (1)

Cardiovascular characterization of children and adolescents with sickle cell anemia

González VN, Graña XL, Díaz ML, Sánchez ET, Rodríguez JB, Machín CI

Language: Spanish
References: 19
Page: 22-32
PDF size: 584.34 Kb.


ABSTRACT

Foundation: sickle cell anemia is a severe chronic hemolytic anemia with a high morbidity and mortality rate. It is well tolerated by the cardiovascular system for a long time, but as years pass, cardiac function is affected.
Objective: to determine the cardiovascular disturbances in patients with sickle cell disease.
Methods: a descriptive and cross-sectional study was conducted in the hematology and cardiology consultations of the Paquito González Cueto de Cienfuegos University Pediatric Hospital from July 1, 2011 to July 31, 2012. The variables analyzed were: age, sex, mean baseline hemoglobin, nutritional status, interrogation and physical examination, bloo.
Results: the predominant age group was 7 to 10 years old, with 52.4 %, with a predominance male sex standing out, baseline hemoglobin between 80 and 90.9g/l represented 57 %. 85.7 % had hepatomegaly and in 71.4 % there was arterial dance, 57.1 % showed systolic murmur and 23.8 % suprasternal beat. 100 % of the cases presented normal electrocardiogram and echocardiogram. The correlation between baseline hemoglobin and nutritional status showed a prevalence of 66.7 % for eutrophic children, with SB thalassemia predominating with 80 %. 57 % presented cardiovascular repercussion mainly the group of 7 to 10 years with 63.6%.
Conclusions: it was possible to identify cardiovascular disturbances through clinic features and a slight impact was observed, confirmed only by the telecardiogram, where the presence of grade l-ll cardiomegaly was identified.


REFERENCES

  1. New Englans Pediatric Sickle Cell Consortium. La anemia falciforme en bebés y niños pequeños [Internet]. New England: NPSCC; 2017 [citado 12 Ago 2019]. Disponible en: http://nepscc.org/2017/wp-content/uploads/2017/ 10/Sickle-Cell-booklet-spv1-proof.pdf

  2. Braunstein E. Anemia de células falciformes [Internet]. E.U: Merck Sharp; 2017 [citado 26 May 2019]. Disponible en: https://www.msdmanuals.com/es/hogar/trastorno s-de-la-sangre/anemia/anemia-de-células-falcifor mes

  3. Svarch E, Hernández P, Ballester JM. La drepanocitosis en Cuba. Rev Cubana Hematol Inmunol Hemoter [revista en Internet]. 2004 [citado 28 Feb 2018];20(2):[aprox. 10p]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext& pid=S0864-02892004000200009

  4. Svarch E, Marcheco B, Machín S, Menéndez A, Nordet I, Arencibia A, et al. La drepanocitosis en Cuba. Estudio en niños. Rev Cubana Hematol Inmunol Hemoter [revista en Internet]. 2011 [citado 18 Nov 2018];27(1):[aprox. 10p]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext& pid=S0864-02892011000100005

  5. García MB, Arango D, Cedré T, García D, López C, Pérez N. Comportamiento de las alteraciones renales en pacientes pediátricos con drepanocitosis. Acta Médica del Centro [revista en Internet]. 2016 [citado 25 Ene 2019];11(1):[aprox. 7p]. Disponible en: http://www.revactamedicacentro.sld.cu/index.ph p/amc/article/view/785

  6. Zivot A, Apollonsky N, Gracely E, Raybagkar D. Body Mass Index and the Association With Vaso occlusive Crises in Pediatric Sickle Cell Disease. J Pediatr Hematol Oncol. 2017;39(4):314-7

  7. Rojas A, Calderón E, Vidal MA, Arroyo F, García R, Torres LM. Crisis drepanocítica y tratamiento del dolor. Rev Soc Esp Dolor [revista en Internet]. 2015 [citado 18 Jul 2019];22(4):[aprox. 20p]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1134-80462015000400004

  8. Ayala AJ, González HJ, David GJ. Anemia de células falciformes: una revisión. Salud Uninorte [revista en Internet]. 2016 [citado 19 Mar 2017];32(3):[aprox. 16p]. Disponible en: http://rcientificas.uninorte.edu.co/index.php/salu d/article/viewArticle/8605

  9. Jitraruch S. Autoimmune Liver Disease in Children with Sickle Cell Disease. J Pediatr. 2017;(1):79-85

  10. Aloni M. Acute Crises and Complications of Sickle Cell Anemia Among Patients Attending a Pediatric Tertiary Unit in Kinshasa, Democratic Republic Of Congo. Hematol Rep. 2017;9(2):6952

  11. Woods GM, Sharma R, Creary S, O'Brien S, Stanek J, Hor K, et al. Venous Thromboembolism in Children with Sickle Cell Disease: A Retrospective Cohort Study. J Pediatr. 2018;197(18):30165-3

  12. Mayo Clinic. Sickle cell Anemia [Internet]. Minnesota: MC; 2016 [citado 10 Oct 2019]. Disponible en: https://ghr.nlm.nih.gov/condition/sickle

  13. Caldas MC, Meira ZA, Barbosa MM. Evaluation of 107 patients with sickle cell anemia through tissue Doppler and myocardial performance index. J Am Soc Echocardiogr. 2008;21(10):1163-7

  14. Zilberman MV, Du W, Das S, Sarnaik SA. Evaluation of left Ventricular diastolic function in pediatric sickle cell disease patients. Am J Hematol. 2007;82(6):433-8

  15. Batra AS, Acherman RJ, Wong W, Wood JC, Chan LS, Ramicone E, et al. Abnormalities in Children With Sickle Cell Anemia. J Am Journal Hematol. 2002;70(1):306-12

  16. Kato GJ, Onyekwere OC, Gladwin MT. Pulmonary hypertension in sickle cell disease: Relevance to Children. Pediatr Hematol Oncol. 2007;24(3):159-170

  17. Barsaoui S, Ben Ameur H, Maherzi A, Oueslati A, Bousnina S. Cardiac manifestations of sickle cell disease. Med Trop (Mars). 1992;52(2):187-90

  18. Klinefelter HF. The heart in sickle cell anaemia. Am J Med Sci. 2002;203(1):34-51

  19. Balfour IC, Covitz W, Davis H, Rao PS, Strong WB, Alpert BS. Cardiac size and function in children with sickle cell anemia. Am Heart J. 1984;108(2):345-50




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