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2019, Number 6

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Rev Mex Pediatr 2019; 86 (6)

Normal levels of urine neutrophil gelatinase-associated lipocalin (u-NGAL) in pre-term and term newborns at 24 and 72 hours of life

Plascencia‑Pimentel K, Bernárdez‑Zapata I, Gerardo‑Del Hoyo MN, Iglesias‑Leboreiro J, Rendón‑Macías ME, Romo‑Vázquez JC, Vicencio‑Rivas J, Lozano‑Duau CM

Language: Spanish
References: 16
Page: 223-228
PDF size: 264.09 Kb.


ABSTRACT

Introduction: The biomarker urinary neutrophil gelatinase-associated lipocalin (u-NGAL) has high excretion in case of ischemia the renal cell loop of Henle and collecting tubule; so far the normal values in neonates are controversial. Objectives: To determine u-NGAL values in healthy newborns at 24 and 72 hours of life, according to weeks of gestation (WG). Material and methods: Seventy neonates (25-32 WG n = 25, 33-35 WG n = 25 y 36-38 WG n = 10; 39-41 WG, n =10). The u-NGAL (ng/mL) levels were determined by chemiluminescence. Values are shown as median as well as minimum and maximum (median [min - max]). Results: u-NGAL levels were different in gestational age group at 24 and 72 hours. 24 hours = 25-32 WG = 18.2 [0.5-543.1], 33-35 WG = 22.3 [0.9-84.4], 36-38 WG = 10.1 [2.5-181.9], 39-41 WG = 20.4 [0-577] ; 72 hours = 25-32 WG = 47.2 [7.5-441.2], 33-35 WG = 33.0 [4.7-235.5], 36-38 WG = 27.7 [4.09-173.1], 39-41 WG = 17.8 [2.0-113.5]. Conclusion: u-NGAL values in neonates seem to increase with gestational age and postnatal life hours; however, more studies are required to determine normal values.


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