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2020, Number 1

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Acta Med 2020; 18 (1)

Transient hyperphosphatasemia

Reyes CAF, Pereira DA
Full text How to cite this article 10.35366/92006

DOI

DOI: 10.35366/92006
URL: https://dx.doi.org/10.35366/92006

Language: Spanish
References: 13
Page: 80-82
PDF size: 115.48 Kb.


Key words:

Hyperphosphatasemia, transient, infant.

ABSTRACT

Transient hyperphosphatasemia (TH) is a benign and selflimited condition in which serum levels of alkaline phosphatase (ALP) are elevated in the absence of other diseases. It is more frequent in children and infants. The differential diagnosis include liver, kidney, bone, intestinal and blood diseases. In this report we present one patient with transient hyperphosphatasemia and provide a review of this disease, which is rarely in clinical practice. The awareness of this condition will avoid unnecessary concerns and investigations.


REFERENCES

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  2. Cho SM, Lee SG, Kim HS, Kim JH. Establishing pediatric reference intervals for 13 biochemical analytes derived from normal subjects in a pediatric endocrinology clinic in Korea. Clin Biochem. 2014; 47 (18): 268-271.

  3. Bach U. Das verhalten der alkalischen serum- phosphatase bei Frughgerborenen. Rachitikern und Spasmophilen. Z Kinderheilk. 1954; 74: 593-609.

  4. Kraut JR, Metrick M, Maxwell NR, Kaplan MM. Isoenzyme studies in transiente hyperphosphatasemia of infancy, in new cases and review of the literature. Am J Dis Child. 1985; 139 (7): 736-740.

  5. Eymann A, Cacchiarelli N, Alonso G, Llera J. Benign transient hyperphosphatasemia of infancy. A common benign scenario, a big concern for a pediatrician. J Pediatr Endocrinol Metab. 2010; 23 (9): 927-30.

  6. Behúlová D, Bzduch V, Holesova D, Vasilenkova A, Ponec J. Transient hyperphosphatasemia of infancy and childhood: Study of 194 cases. Clin Chem. 2000; 46 (11): 1868-1869.

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  8. Otero JL, González-Peralta RP, Andres JM, Jolley CD, Novak DA, Haafiz A. Elevated alkaline phosphatase in children: An algorithm to determine when a “Wait and See” approach is optimal. Clin Med Insights Pediatr. 2011; 5: 15-18.

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  10. Lo SF. Reference Intervals for Laboratory Tests and Procedures. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia: WB Saunders; 2011: 2466.

  11. Kutilek S, Cervickova B, Bebova P Kmonickova M, Nemec V. Normal bone turnover in transient hyperphosphatasemia. J Clin Res Pediatr Endocrinol. 2012; 4 (3): 154-156.

  12. Turan S, Topcu B, Gökçe İ, Güran T, Atay Z, Omar A et al. Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets. J Clin Res Pediatr Endocrinol. 2011; 3 (1): 7-11.

  13. Carroll AJ, Coakley JC. Transient hyperphosphatasaemia: an important condition to recognize. J Paediatr Child Health. 2001; 37: 359-62.




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Acta Med. 2020;18