2006, Number 2
Rev Med Hosp Gen Mex 2006; 69 (2)
Paniagua-Contreras GL, Monroy-Pérez E, Alonso-Trujillo J, Vaca-Pacheco S, Negrete-Abascal E, Pineda-Olvera J
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ABSTRACTObjective: The purpose of the study was to evaluate the prevalence of surgical wound infections in patients after discharge from the hospital, and the effectiveness of antibiotics against the bacterial strains isolated. Method: One-hundred-seventy-four patients who underwent surgical procedures in a General Hospital were analyzed. Bacteria were identified by API-STAPH and API20E systems. The minimal inhibitory concentrations (MICs) of antibiotics were determined by plate dilution test. Results: One hundred eighteen patients (67.8%) showed surgical wound infections, and 137 bacterial strains were identified. All Gram-positive strains [Staphylococcus aureus (70%) and coagulase-negative Staphylococci (15.3%)] were resistant to penicillin, ampicillin (MIC90= 225 µg/mL for both drugs), dicloxacillin (MIC90= 112.5 µg/mL), cefalotine (MIC90= 113 µg/mL), and cefuroxime (MIC90= 223 µg/mL), but sensitive to vancomycin and ampicillin plus sulbactam (MIC90= 3.5 µg/mL for both drugs). All Gram-negative strains [Escherichia coli (9.5%) and Klebsiella ozaenae (5.1%)] were resistant to ampicillin (MIC90= 225 µg/mL) and cefalotine (MIC90= 51 µg/mL) but sensitive to cefuroxime (MIC90= 6 µg/mL), cefotaxime (MIC90= 3.7 µg/mL), and ampicillin plus sulbactam (MIC90= 3.7 µg/mL). All Gram-negative and 65% Gram-positive strains produced betalactamases. Conclusion: Results show a high prevalence of postsurgical infections caused by antibiotic-resistant bacteria, and suggest the need for postdischarge follow-ups for surgical patients.