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Revista Médica Sinergia

2020, Number 02

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Revista Médica Sinergia 2020; 5 (02)

Skin microbiome, dysbiosis and its role in atopic dermatitis

Ruiz GD, Barquero OD

Language: Spanish
References: 37
Page: 320-320
PDF size: 193.44 Kb.


ABSTRACT

The skin microbiome is composed of an extensive variety of microorganisms and it can be modified by different factors and suffers changes through life as a dynamic process. The host and the microorganisms have a symbiotic relationship, at the time this system suffers changes appears a status of dysbiosis and this process has influence on diseases such as atopic dermatitis. Some authors state the high rate of colonized patients by Staphylococcus aureus and this is supported by many of the studies that compare lesional versus non lesional skin in this population. Other factors such as mutations on the protein called filaggrin increases the susceptibility of bacterial colonization (S.aureus). On the other hand, some microbial agents have been found to have inhibitory properties over pathogens and are thought to have a protective role becoming possible novel therapies. Furthermore, it is mentioned that conventional treatments (corticosteroids, phototherapy, calcineurin inhibitors and moisturizer) helps to reestablish the normal composition of the microbiome. Multiple strategies are being studied in attempt of addressing the dysbiosis process related with atopic dermatitis.


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