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2020, Number 2

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Acta Pediatr Mex 2020; 41 (2)

Glomerular anti-basement membrane glomerulonephritis post-kidney transplant in a teenager with Alport syndrome. Case report

Calderón-Mendieta FJA, García-de la Puente S, Razo-Paredes NG, Macías-Díaz DM, Burciag-Verduzco MA

Language: Spanish
References: 15
Page: 66-71
PDF size: 427.77 Kb.


ABSTRACT

Background: The overall incidence of post-transplant antiglomerular basement membrane in patient transplanted from Alport syndrome is about 5%, being more frequent in men and in the first year of the transplant.
Clinical case: Female patient of 19 years, with histopathological diagnosis of Alport syndrome at 13 years, transplanted at 18 years. He had a picture of sudden graft dysfunction at 20 months after the transplant. Renal dysfunction was resistant to treatment and had graft loss at 8 weeks. The renal biopsy was diagnosed: glomerular basal glomerulonephritis.
Conclusions: Although antiglomerular basement membrane glomerulonephritis it’s a low frequency entity in the setting of patient transplanted from Alport Syndrome, it has to raise the possibility of this disease when the usual therapeutic fail, because there is a high rate of graft loss (75%) the development of new strategies for this type of patients is needed.


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