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Federación Mexicana de Ginecología y Obstetricia, A.C.

2020, Number 06

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Ginecol Obstet Mex 2020; 88 (06)

Combination of uric acid and serum albumin as predictive biomarkers of severe preeclampsia

Hidalgo-Carrera JA, Linder-Efter C, Chaya-Hajj M, Von der Meden-Alarcón JW, Rodríguez-Lane R, Ramírez-Valencia MF

Language: Spanish
References: 19
Page: 357-362
PDF size: 239.99 Kb.


ABSTRACT

Objective: To determine if the combination of serum uric acid and albumin levels from weeks 20 to 24 of gestation are predictors of severe preeclampsia.
Materials and Methods: A retrospective and observational case-control study was carried out, in which the levels of uric acid and albumin taken during the 20th to 24th week were analyzed and compared with patients who developed severe preeclampsia. The data was collected in Microsoft Excel for Mac version 2019 and the statistical analysis was performed in SPSS for Mac version 25.
Results: 122 cases and 199 controls were obtained. Elevation of uric acid levels (≥4.9 mg/dL) and hypoalbuminemia (‹3.5 mg/dL) obtained statistical significance for severe preeclampsia compared to the control group (p ‹0.001). The logistic regression model obtained an OR to predict severe preeclampsia of 6.736 (CI95% 2.5-17.7) for uric acid elevation and OR of 11.337 (CI95% 4.5-28.3) for hypoalbuminemia (p ‹0.001).
Conclusion: In this study the statistically significant relationship was observed between the increase in uric acid levels and serum hypoalbuminemia from weeks 20 to 24 as predictive biomarkers of severe preeclampsia. However, more studies should be carried out to verify its clinical utility.


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