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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2020, Number 2

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Rev Biomed 2020; 31 (2)

Depressive and antidepressant indices during the forced swim test are differentially associated with the seasonality and estrous cycle in female Wistar rats

Jaffar-Medina V, Rosado-Pérez AL, Flores-Serrano AG, Torres-Escalante JL, Pineda JC

Language: Spanish
References: 21
Page: 69-75
PDF size: 660.88 Kb.


ABSTRACT

Introduction. Both, the influence of antidepressant drugs and the antidepressant behaviors in animal models are conditioned both by seasons of the year and by estrus stage in depressive individuals. However, at present, the influence of these factors remains poorly studied in the animal models. In the forced swimming test (FST) the depressant indexes are referred to the basal behavior produced in the early five minutes of the test. In this period, unconditioned depressant- and antidepressant-like behaviors are developed, and they are the control parameter of the model, which are used as the basal index to compare the depressive-like indexes in its second part of the test. Estrous cycle and season affect this test. However, the influences of these factors have not been studied.
Objective. Identify the influence of season and estrous cycle on the depressant- (immobility time; IT) and antidepressant-like indexes (CT and ST) in the forced swimming in a basal condition.
Methods. We measured depressive and antidepressant index, during a five minute session of forced swimming, at different seasons of the year and estrous stages in female Wistar rats.
Results. While no differences in the open field test were detected in different seasons, the IT was larger in the summer or autumn, than in winter during the forced swim. While ST was larger in the winter than summer or autumn only during diestrus stage. The estrous stage length, but not the estrous cycle length, was longer in summer than winter.
Conclusion. These results suggest that estrous cycle and seasons of the year are involved differentially and selectively in adaptive responses to stress produced during time learning in FST in female rats and may help in developing indices to predict sensitivity or resilience in depression.


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