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Federación Mexicana de Ginecología y Obstetricia, A.C.

2020, Number S1

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Ginecol Obstet Mex 2020; 88 (S1)

Transdermal contraception

Cortés-Bonilla M, Velázquez-Ramírez N

Language: Spanish
References: 8
Page: 42-46
PDF size: 218.78 Kb.


ABSTRACT

Transdermal contraception is a combined hormonal treatment scheme, based on the administration of an estrogenic derivative and a synthetic gestagen from 19-nortestosterone. The comercial presentation of the drug consists of a patch of 6 mg of norelgestromine (active metabolite of norgestimate: a progestagen of third generation) and 600 μg of ethinyl-estradiol, which release daily into the circulation 150 and 20 μg, respectively. It is an adhesive patch, applied once a week for three weeks, followed by a week off; it is not necessary to apply it at the same hour, its use is quite lax in this respect. The transdermal contraceptives represent the best option of attachment to the treatment of this type of drugs. The elimination of the liver passage allows the prescription with lower doses of ethinylestradiol. Transdermal contraception is a method with high efficacy, it can even be prescribed to patients with hyperandrogenism.


REFERENCES

  1. Hernández MI, et al. Anticoncepción. Medicina de la Reproducción humana. 2ª ed. Editores de Textos Mexicanos: México, 2006;333-344.

  2. Zieman M, et al. Contraceptive efficacy and cycle control with Evra transdermal system: The analysis of pooled data. Fertil Steril 2002;77(Supl 2):13-18. Doi: https://doi. org/10.1016/50015-0282(01)03275-7

  3. Abrams LS, et al. Pharmacokinetics of norelgestromin and ethinyldestradiol from two consecutive contraceptive patches, J Clin Pharmacol 2001;41:1232. Doi: https://doi. org/10.1177/00912700122012788

  4. Burkman RT. The transdermal contraceptive system. Am J Obstet Gynecol 2004;190:S49-S53. Dio: https://doi. org/10.1016/j.ajog.2004.01.060

  5. Zacur HA, et al. Integrated summary of Otho Evra. Contraceptive patch adhesion in variate climates and conditions. Fertil Steril 2002;77(Suppl 2):S32-S35. Doi: 10.1016/S0015- 0282(01)03262-9

  6. González CM. Anticoncepción. Ginecología. 9ª ed. Elsevier Masson: Madrid, 2014.

  7. Speroff L, et al. Endocrinología ginecológica clínica y esterilidad. 2ª ed. Wolters Kluwer Health: Barcelomna, 2006.

  8. Galzote RM, et al. Transdermal delivery of combined hormonal contraception: A review of the current literature. Int J Womens Health 2017;9:315-321. Doi:10.2147/IJWH.S102306




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