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2020, Number 2

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Rev Hematol Mex 2020; 21 (2)

Breast cancer as initial manifestation of acute lymphoblastic leukemia

Plata-Corona JC, Juan-Lien Chang LE, Camacho-Becerra C

Language: Spanish
References: 19
Page: 120-126
PDF size: 267.33 Kb.


ABSTRACT

Background: Extramedullary infiltration of acute lymphoblastic leukemia (ALL) in adults as an initial manifestation is rare and represents a diagnostic and therapeutic challenge. It is known that ALL is able of infiltrating any organ, the most common is central nervous system and testicle, breast infiltration is an exceptional location.
Clinical case: A 34-year-old woman, whose clinical condition started with two tumor lesions in the right breast which were initially documented as probable breast cancer, eventually developed purpuric, hemorrhagic and febrile syndrome; patient was then protocolized by the hematology department, peripheral blood smears, bone marrow aspirate and fine-needle aspiration cytology (FNAC) was performed. The presence of blasts in peripheral blood and bone marrow was concluded, corresponding by morphology to ALL L3, the cytological analysis of FNAC also identified blasts, and it was finally diagnosed of ALL L3 with breast infiltration.
Conclusion: Breast infiltration by ALL is rare. It should be considered in the differential diagnosis of malignancy. In an appropriate context fine-needle aspiration cytology is an acceptable method to establish diagnosis and may avoid unnecessary surgical biopsies that condition sequels in young female.


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