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2019, Number 1

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Rev Cubana Farm 2019; 52 (1)

Phytochemical and toxicological characteristics of Swietenia humilis Zuccarini seed and its hypoglycemic effect

Flores LZY, Campos DAP, Quiroga SEH, Gutiérrez GY, Salas OE, García SG, Cuellar CA

Language: Spanish
References: 15
Page: 1-12
PDF size: 537.73 Kb.


ABSTRACT

Introduction: Swietenia humillis Zuccarini seed is known among the indigenous population of Mexico as “zopilote seed”, and it is traditionally consumed as against diabetes and antiparasitic infusion. Despite being part of herbalist knowledge in Mexico, there are few scientific reports of the phytochemical, toxicological and hypoglycemic characteristics of the seed and on the way it can be consumed.
Objective: To verify the absence of acute oral toxicity of aqueous extract from Swietenia humilis Zuccarini seed and its hypoglycemic effect in female Wistar rats.
Methods: Some pharmacognostic parameters were determined in the raw drug, and it was prepared an aqueous extract of the seed by infusion for phytochemical screening and analysis of acute oral toxicity and hypoglycemic effect. Adult female Wistar rats from the National Center for the Production of Laboratory Animals (CENPALAB, by its acronym in Spanish), Cuba, were used and metformin was used as control.
Results: Alkaloid type and phenolic compounds were identified by phytochemical screening; the administration of the aqueous extract in rats did not affect their metabolic and digestive processes, any rat showed signs of toxicity throughout the study. It is shown that the aqueous extract has a hypoglycemic effect in Wistar rats when compared with metformin.
Conclusions: These results prove the hypoglycemic effect and innocuousness of the seed in its traditional use as a natural alternative in the control of hyperglycemia.


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