Durón-Vázquez D, Tapia-Amador G, Lemini-López A, Castellanos-Pacheco G, Delgado-López N

Language: Spanish
References: 11
Page: 115-117
PDF size: 168.33 Kb.

ABSTRACT

Histiocytic sarcoma (hs) is an infrequent and aggressive neoplasm. It represents less than 1% of all malignancies of the hematopoietic system, and 7% of the cases corresponds to the cutaneous variety. It is characterized by maculo-papular erythema or nodules that can ulcerate. We report a 59-year-old male with an eight-month history of asymptomatic, disseminated dermatosis in limbs and thorax, characterized by four violaceous nodules of progressive growth. A bone marrow biopsy was performed and tricholeukemia was demonstrated discarding neuroendocrine carcinoma and concluding hs limited to skin and tricholeukemia. Later manifests splenomegaly and “hairy” cells. Immunophenotype: cd45, cd4, cd68, lysozyme (+); s100, cd1a, myeloperoxidase (–); Ki 67 (20%). There are isolated reports on its association with tricholeukemia, where identical molecular and cytogenetic alterations have been documented. The diagnosis is clinical and immunohistochemical with cd45+ and two markers of histiocytes. In this case treatment of choice for hs was surgical excision.

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