Rodríguez-Torres Z, Robles-Sainz LR

Language: Spanish
References: 16
Page: 30-34
PDF size: 546.02 Kb.

ABSTRACT

The incidence of bladder cancer increases rapidly, being attributed by 20-25% with some type of occupational exposure to aromatic amines. Our objective was to review and report a case to demonstrate the presence of risk factors, their incidence and their low recognition to present urothelial bladder tumors. 43-year-old male, saddler since the age of 10. With a history of painless macroscopic hematuria with the presence of clots at the end of diuresis since the age of 22, in whom he was diagnosed with an undifferentiated invasive muscle tumor of histopathological characteristics T2b, N0, M0. This article demonstrates the direct correlation between the exposure factors to carcinogenic agents with the early and aggressive presentation of the bladder tumor, being a key factor for recurrence and tumor progression.

REFERENCES

1. Suárez B, Encarnacion E & Valladares L. Revisión bibliografíca de cáncer vesical de origen laboral. Med Segur Trab. 2015; 61(239): 295-310.

2. Cheng L, Beltran A, Gregory T, MacLennan, Montironi R & Bostwick G.Neoplasms of the Urinary Bladder. Urologic Surgical Pathology. 4th. Ed. EE. UU: ELSEVIER. 2020, p. 230-321.e19.

3. Marilyn L. Kwan, Brandon Garren, Matthew E. Nielsen, Li Tang. Lifestyle and nutritional modifiable factors in the prevention and treatment of bladder cancer. Urologic Oncology. 2019; 37(6): 380- 386.

4. Ángela B, Smith A, Arjun V, Ballar, Matthew I, Milowsky, Ronald C. Carcinoma of the Bladder. Clinical Oncology. 6th. Ed. EE.UU: ELSEVIER. 2020, p. 1382-1400.

5. García M, Ávila M, Barrabas A & Dale L. Bacillus Calmette Guérin inmmunotherapy in the treatment of superficial bladder cáncer. Rev Mex de Urología. 2009; 307-313.

6. Zhu Z, Zhang J, Jiang W, Zhang X, Li Y, et. al. Risks on N-acetyltransferase 2 and bladder cancer: a metaanalysis. Onco a Ther. 2015; 8: 3715-3720.

7. Wein A, Kavousii, Novick, Partin, Peters. Tumores uroteliales de la vejiga. Campbell-Walsh Urology. España: Panamericana. 2015, p. 2333-2355.

8. Dietrich H. & Dietrich B. Ludwig Rehn (1849-1930) pioneering findings on the aetiology of bladder tumours. World J of Urology. 2001; 151-153.

9. Shuang W, Daniel H, Kim S & Denis M. Primary aromatic amines and cnacer: Novel mechanistic insights using 4-aminobiphenylas a model carcinogen. Pharmacology & Therapeuctics. 2019; 179- 189.

10. Hueper W. Experimental production of bladder tumors in dogs by administraion of betanaphthylamine. J of Industrial Hygiene and toxicology. 1937; 113-133.

11. Thiede T, Chistensen B. Bladder tumours induced by chlornaphazine. A five years follow up study of clornaphazine treated patients with polpycythaemia. Acta Medica Scandinavica. 1969: 133-137.

12. Hein D. N-acetyltransferase 2 genetic polyporhism: effects of carcinogen and haplotype on urinary bladder cancer risk. Oncogene. 2006; 25(11): 1649- 1658.

13. Raoul C, Eliane K, Frank B, Marre B & Maurice P. A meta-analysis on the association between bladder cancer and ocupation. Scandinavia Journal of Urology and Nephrology. 2008; 42(Suppl 218): 64-79.

14. Moore L, Baris D, Figuero J, Garcia M, Karagas M, et al. GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis. Carcinogenesis. 2011; 32(2): 182-189.

15. Tean B, Eric R. Genetic and Epigenetic Alterations in Cancers, Abeloff's Clinical Oncology. 6th. Ed. EE.UU: ELSEVIER. 2020. p. 209-224.

16. Restrepo M., Hurtado M., Camacho M., Garcia A., Osorio M., & Camargo J. Manual de agentes carcinógenos de los grupos 1 y 2ª de la IARC, de interés ocupación para Colombia. Instituto Nacional de Cancerología; 2006.