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2020, Number S2

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Rev Mex Traspl 2020; 9 (S2)

COVID-19: Clinical features and diagnosis

Parra-Avila I

Language: Spanish
References: 29
Page: 160-166
PDF size: 300.48 Kb.


ABSTRACT

In general population, the clinical picture of SARS-CoV-2 infection is characterized by symptoms such as fever, cough and fatigue. Incubation period ranges from 5 or 6 days to 14 days, generally they are mild cases with outpatient management and only 30% will be admitted in hospital. Main risk factors for severe disease are: age ≥ 65 years, obesity, arterial hypertension, diabetes mellitus, coronary heart disease, obstructive pulmonary disease, and malignancies. General mortality is around 5% but may be higher in critically ill patients. In transplant recipients, who are under immunosuppression, it is expected that clinical picture, laboratory and imaging findings could be different compared with general population, as has been observed with other kind of infections. However, in several published reports, there are no differences with non-transplanted population. Although clinical picture may be mild, frequency of complications is more common in transplanted population. Mortality is around 20%, higher than non-transplanted population. Molecular diagnosis with RT-PCR is defined as the gold standard, however its sensitivity is below 80%. Undoubtedly, the epidemiological circumstances, clinical suspicion, RT-PCR report and imaging tests are complementary to establishing a correct diagnosis.


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