medigraphic.com
Revista Médica Sinergia

2020, Number 07

Next >>

Revista Médica Sinergia 2020; 5 (07)

Disseminated intravascular coagulation in the patient with sepsis

Maya CA, Cartín RAC, Osejo RMS

Language: Spanish
References: 21
Page: 1-10
PDF size: 145.68 Kb.


ABSTRACT

Sepsis is a highly inflammatory infectious process associated with high mortality and multiple complications. One of these complications is disseminated intravascular coagulation and can be seen in almost half of patients with sepsis. Multiorgan disfunction syndrome is a final consequence of disseminated intravascular coagulation, therefore it’s not rare to find a relatively high mortality in patients with both sepsis and disseminated intravascular coagulation. Pathogenesis of disseminated intravascular coagulation is attributed to a coagulation disfunction initiated by tissue factor, with dissemination of microthrombus and acceleration of coagulation factors consumption. The final result is the disfunction of multiple organs, different hemorrhagic disturbances, and in the worst-case scenario, death. The aim of the actual management of disseminated intravascular coagulation is to treat the underlying disease, in this case the treatment of the pathogen, and the use of supporting therapy with anticoagulant treatment to ameliorate clinical outcomes.


REFERENCES

  1. Iba T, Ito T, Maruyama I, Jilma B, Brenner T, Müller MC, et al. Potential diagnostic markers for disseminated intravascular coagulation of sepsis. Blood Reviews. 2016;30(2):149–55. https://doi.org/10.1016/j.blre.2015.10.002

  2. Iba T, Thachil J. Present and future of anticoagulant therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation: a perspective from Japan. International Journal of Hematology. 2015Nov20;103(3):253–61. https://doi.org/10.1007/s12185-015-1904-z

  3. T, Shoko T, Deguchi Y. Clinical Investigation of Coagulation Markers for Early Detection of Sepsis-Induced Disseminated Intravascular Coagulation: A Single-Center, Prospective Observational Study. Clinical and Applied Thrombosis/Hemostasis. 2018Mar18;24(7):1082–7. https://doi.org/10.1177/1076029618762473

  4. Tsao C-M, Ho S-T, Wu C-C. Coagulation abnormalities in sepsis. Acta Anaesthesiologica Taiwanica. 2015;53(1):16–22. https://doi.org/10.1016/j.aat.2014.11.002

  5. Park JY, Park S, Park SY, Sim YS, Kim JH, Hwang YI, et al. Day 3 versus Day 1 Disseminated Intravascular Coagulation Score among Sepsis Patients: A Prospective Observational Study. Anaesthesia and Intensive Care. 2016Jan;44(1):57–64. https://doi.org/10.1177/0310057X1604400110

  6. Kudo D, Hayakawa M, Ono K, Yamakawa K. Impact of non-anticoagulant therapy on patients with sepsis-induced disseminated intravascular coagulation: A multicenter, case-control study. Thrombosis Research. 2018;163:22–9. https://doi.org/10.1016/j.thromres.2017.12.022

  7. Kudo D, Hayakawa M, Ono K, Yamakawa K. Impact of non-anticoagulant therapy on patients with sepsis-induced disseminated intravascular coagulation: A multicenter, case-control study. Thrombosis Research. 2018;163:22–9. https://doi.org/10.1016/j.thromres.2017.12.022

  8. Levi M. Pathogenesis and diagnosis of disseminated intravascular coagulation. International Journal of Laboratory Hematology. 2018;40:15–20. https://doi.org/10.1111/ijlh.12830

  9. Levi M, Sivapalaratnam S. Disseminated intravascular coagulation: an update on pathogenesis and diagnosis. Expert Review of Hematology. 2018Jul20;11(8):663–72. https://doi.org/10.1080/17474086.2018.1500173

  10. Umemura Y, Yamakawa K. Efficacy and safety of anticoagulant therapy in three specific populations with sepsis: a meta-analysis of randomized controlled trials: reply. Journal of Thrombosis and Haemostasis. 2016;14(11):2310–1. https://doi.org/10.1111/jth.13473

  11. Thachil J. Disseminated intravascular coagulation – new pathophysiological concepts and impact on management. Expert Review of Hematology. 2016Jun17;9(8):803–14. https://doi.org/10.1080/17474086.2016.1203250

  12. Okuda A, Ogura T, Imanishi M, Miyano A, Nishioka N, Higuchi K. Clinical Impact of Recombinant Soluble Thrombomodulin for Disseminated Intravascular Coagulation Associated with Severe Acute Cholangitis. Gut and Liver. 2018Jul15;12(4):471–7. https://doi.org/10.5009/gnl17489

  13. Iba T, Thachil J. Present and future of anticoagulant therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation: a perspective from Japan. International Journal of Hematology. 2015Nov20;103(3):253–61. https://doi.org/10.1007/s12185-015-1904-z

  14. Ikeda M, Matsumoto H, Ogura H, Hirose T, Shimizu K, Yamamoto K, et al. Circulating syndecan-1 predicts the development of disseminated intravascular coagulation in patients with sepsis. Journal of Critical Care. 2018Feb;43:48–53. https://doi.org/10.1016/j.jcrc.2017.07.049

  15. Walborn A, Rondina M, Mosier M, Fareed J, Hoppensteadt D. Endothelial Dysfunction Is Associated with Mortality and Severity of Coagulopathy in Patients with Sepsis and Disseminated Intravascular Coagulation. Clinical and Applied Thrombosis/Hemostasis. 2019;25:107602961985216. https://doi.org/10.1177/1076029619852163

  16. Levi M, van der Poll T. Coagulation and sepsis. Thrombosis Research. 2016Nov19;149:38–44. https://doi.org/10.1016/j.thromres.2016.11.007

  17. Delabranche X, Quenot J-P, Lavigne T, Mercier E, François B, Severac F, et al. Early Detection of Disseminated Intravascular Coagulation During Septic Shock. Critical Care Medicine. 2016;44(10). https://doi.org/10.1097/CCM.0000000000001836

  18. Umemura Y, Yamakawa K, Hayakawa M, Kudo D, Fujimi S. Concomitant Versus Individual Administration of Antithrombin and Thrombomodulin for Sepsis-Induced Disseminated Intravascular Coagulation: A Nationwide Japanese Registry Study. Clinical and Applied Thrombosis/Hemostasis. 2018Feb22;24(5):734–40. https://doi.org/10.1177/1076029618755948

  19. Hayakawa M, Yamakawa K, Kudo D, Ono K. Optimal Antithrombin Activity Threshold for Initiating Antithrombin Supplementation in Patients With Sepsis-Induced Disseminated Intravascular Coagulation: A Multicenter Retrospective Observational Study. Clinical and Applied Thrombosis/Hemostasis. 2018Aug;24(6):874–83. https://doi.org/10.1177/1076029618757346

  20. Akahoshi T, Sugimori H, Kaku N, Tokuda K, Nagata T, Noda E, et al. Comparison of recombinant human thrombomodulin and gabexate mesylate for treatment of disseminated intravascular coagulation (DIC) with sepsis following emergent gastrointestinal surgery: a retrospective study. European Journal of Trauma and Emergency Surgery. 2014Nov20;41(5):531–8. https://doi.org/10.1007/s00068-014-0478-4

  21. Umemura Y, Yamakawa K, Hayakawa M, Hamasaki T, Fujimi S. Screening itself for disseminated intravascular coagulation may reduce mortality in sepsis: A nationwide multicenter registry in Japan. Thrombosis Research. 2018;161:60–6. https://doi.org/10.1016/j.thromres.2017.11.023




2020     |     www.medigraphic.com