medigraphic.com
ISSN 1729-519X (Print)

2020, Number 1

<< Back Next >>

Revista Habanera de Ciencias Médicas 2020; 19 (1)

Splenic metastasis from endometrial adenocarcinoma. A case presentation

Montero LJF, Escalona RTR, Álvarez SS

Language: Spanish
References: 17
Page: 102-111
PDF size: 762.61 Kb.


ABSTRACT

Introduction: Splenic metastasis from endometrial carcinoma is a rare clinical event with only 13 documented cases in the literature reviewed. The evolution of a patient with this metastasis attended in our institution was the reason that motivated us to publish this work. There are other oncological diseases that are accompanied by this clinical picture during their evolution of progression where surgical treatment complemented with chemotherapy treatment is essential. A literature review was carried out in Cuban publications, but no reports on the topic were found.
Objective: The aim of this work is to present an endometroid type case endometrium adenocarcinoma which metastasizes to the spleen with clear cell histology.
Case presentation: Forty-five-year-old patient with diagnosis of endometrium adenocarcinoma with surgical stage pT3a Nx Mo stage IIIA Grade ‘2; this quantification was defined before 2009. The patient underwent surgical treatment which was complemented with radiotherapy and then followed for 21 months. In the follow-up consultation, spleen metastasis was diagnosed; so she underwent splenectomy and was treated with chemotherapy. She was treated by the multidisciplinary gynecologic oncology team; the investigations performed were based on immuhistochemistry, imaging, and supportive treatment whenever needed.
Conclusions: Splenic metastasis from endometrial cancer is rare; it is the first case reported in Cuba. Immuhistochemical and imaging studies are essential.


REFERENCES

  1. World Health Organization [Internet]. Geneva: WHO; c2017.AWorld Health Statistics. Monitoring health for the SDGs; 2016.

  2. American Cancer Society. Estadísticas importantes sobre el cáncer de endometrio. [Internet]. EU: American Cancer Society; 2018 [Citado:15/12/2018]. Disponible en: https://www.cancer.org/es/cancer/cancer-deendometrio/ acerca/estadisticas-clave.html

  3. García Cegarra PM, Esquinas Vega MC, Gómez Leal P, Donzo Tobele M, Martínez Martínez A, Jiménez García A. Metástasis esplénica de adenocarcinoma endometrial. A propósito de un caso. España: Hospital General Universitario “Santa Lucía”. XXVII Reunión Sociedad Ginecológica Murciana. Salón de Actos del Hospital Comarcal del Noroeste-Caravaca de la Cruz; 2017.

  4. Piura B, Rabinovich A, Apel-Sarid L. Shaco-Levy R. Splenic Metastasis from endometrial carcinoma: report of case and review of literature. Arch Gynecol Obstet [Internet]. 2009 Apr [Citado::15/12/2018]; 280(6):1001-6.. Disponible en:https://www.researchgate.net/publication/24219 399_Splenic_metastasis_from_endometrial_carcino ma_Report_of_a_case_and_review_of_literature

  5. Kyser S, Koren R, Klein B, Chaimoff C. Giant splenomegaly caused by splenic metastases of melanoma. Eur J Surg Oncol [Internet]. 1998 Aug[Citado:15/12/2018];24:336-337Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/9725006

  6. Furukawa N. Solitary splenic metastases of ovarian cancer. Arch Gynecol Obstet [Internet]. 2007 Jun [Citado:15/12/2018] ;275(6):499-502. Disponible en: https://link.springer.com/article/10.1007%2Fs00404- 006-0274-4

  7. Sohaib SA, Houghton SL, Meroni R, Rockall AG, Blake P, Reznek RH. Recurrent endometrial cancer: patterns of recurrent disease and assessment of prognosis. Clin Radiol [Internet]. 2007 [Citado:15/12/2018] ; 62(1):28-34. Disponible en: https://www.researchgate.net/publication/6654321 _Recurrent_endometrial_cancer_Patterns_of_recurr ent_disease_and_asse

  8. Takahashi H, Yano H, Monden T, Kinoshita T. Handassited laparascopy splenectomy for solitary splenic metastases from uterine corpus carcinoma. Surg Endosc [Internet]. 2004 [Citado:15/12/2018] ; 18(2):346. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/15106624

  9. Bristow RE, Santillan-Gomez A, Zahurak ML, Gardner GJ, Giuntoli RL, Armstrong DK. Salvage cytoreductive surgery of recurrent endometrial cancer. Gynecol Oncol [Internet]. 2006 Oct [Citado:15/12/2018] ;103(1):281-7. Disponible en: https://jhu.pure.elsevier.com/en/publications/salvag e-cytoreductive-surgery-for-recurrent-endometrialcancer- 4

  10. Sauer J, Sobolewski K, Dommisch K .Splenic metastases not a frecuent problem, but and underestimate location of metastases: epidiomiology and course. J Cancer Res Clin Oncol [Internet]. 2008 Nov [Citado:15/12/2018] ;135(5):667-71. Disponible en: https://www.researchgate.net/publication/2339996 7_Splenic_metastases_- _Not_a_frequent_problem_but_an_underestimate_

  11. Lee SS, Morgenstern L, Phillips EH, Hiatt JR, Margulies DR. Splenectomy for splenic metastases: a changing clinical spectrum. Am Surg 2000; 66: 837-40.

  12. Awtrey CS, Candungog MG, Leitao MM, Alektiar KM ,Aghajanian C, Hummer AJ, et al .Surgical resection of recurrent endometrial carcinoma. Gynecol Oncol [Internet]. 2006 Sep [Citado:15/12/2018] ;102(3):480-8. Disponible en: https://www.sciencedirect.com/science/article/pii/S 0090825806000345

  13. Lam KY, Tang V. Metastic tumors to the spleen : a 25-year clinicopathology study. Ach Pathol Lab Med [Internet]. 2000 [Citado:15/12/2018] ;124(4): 526- 30.Disponible en: https://www.researchgate.net/publication/1256964 7_Metastatic_tumors_to_the_spleen_A_25- year_clinicopathologic_study

  14. Kinoshita A, Nakano M,Fukuda M, Kasai T,Suyama N,Inou K, et al. Splenic metastases from lung cancer. Neth J Med [Internet]. 1995 Nov [Citado:15/12/2018] ; 47(5):219-23. Disponible en: https://www.sciencedirect.com/science/article/pii/0 300297795000118

  15. Morris M, Geshenson DM, Burke TW, Wharton JT,Copeland LJ,Rutledeg FN .Splenectomy in gynecologic Oncol [Internet]. 1991 [Citado:15/12/2018] ; 43(2):118-122. Disponible en: https://www.gynecologiconcologyonline. net/article/0090-8258(91)90056-B/fulltext

  16. Farias-Eisner R, Braly P,Berek JS. Solitary recurrent metastases of epithelial ovarian cancer in the spleen. Gynecol Oncol [Internet]. 1993 [Citado:15/12/2018] ;48(3):338-41. Disponible en: https://www.gynecologiconcologyonline. net/article/S0090-8258(83)71059-0/fulltext

  17. Berge T. Splenic metastases. Frequencies and patterns. Acta Pathol Microbiol Scand [Internet]. 1974 Jul [Citado:15/12/2018] ;82(4):499-506. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/4854372




2020     |     www.medigraphic.com