Prado-Zavala LM, Campos-Pérez Y, Ayala-Aceves F, Carranza-Madrigal J

Language: Spanish
References: 11
Page: 476-484
PDF size: 207.70 Kb.

ABSTRACT

Background: Endothelial dysfunction is the first step towards atherosclerosis. There are well-known risk factors such as diabetes, hypertension, dyslipidemia and smoking, and in recent times foods have also been recognized as modifiers of endothelial function.
Objective: To evaluate the effect on endothelium in healthy subjects of 4 types of food.
Material and Method: A clinical, experimental, comparative, prospective, blinded for the evaluator, trial, to investigate the effect of different diets on endothelial function, by flow-mediated vasodilation, in healthy males. The evaluation was carried out basal and at 4 hours after ingestion of a diet rich in saturated animal fats (whole milk and burger), saturated vegetable fats (sugar-sweetened donuts and vegetal oil added milk), monounsaturated fats (avocado sandwich with light milk) and simple carbohydrates (watermelon and orange juice), isocaloric with each other, with a separation of at least 7 days.
Results: There were included 16 subjects. The average age of the subjects evaluated was 23.5 ± 2.5 years. A baseline endothelial dysfunction was found in 73% of the subjects, with a tendency to improve function in the subjects after receiving the diets containing avocado and fruit. The avocado was the diet that normalized the endothelial function of more subjects in relation to their basal state, from 12.5 to 31.25%, unlike the rest of the diets that after consumption led to an index of positive dysfunction.
Conclusions: There is a high frequency of endothelial dysfunction among apparently healthy young men. Diets rich in monounsaturated fats improve the arterial vasodilation profile and normalize endothelial function in more subjects compared to the other diets.

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