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Revista Médica Sinergia

2020, Number 08

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Revista Médica Sinergia 2020; 5 (08)

Organophosphate poisoning

Orias VM

Language: Spanish
References: 16
Page: 1-9
PDF size: 142.79 Kb.


ABSTRACT

Organophosphates are one of the most widely used insecticides in agriculture and domestic use, poisonings occur from occupational exposure and from voluntary intake. It works by developing its toxicity in the nerve endings through the hydrolysis of acetylcholine, the enzyme responsible for hydrolyzing acetylcholine. The clinical picture generates a characteristic syndrome, with cholinergic symptoms (bronchorrhea, salivation, tearing, bronchospasm, defecation, emesis, miosis, among others) due to the stimulation of muscarinic and nicotinic receptors. Diagnosis is made through a medical history and physical examination. Additionally, you can help with cabinet exams like detecting metabolites in the urine. Currently treatment Intoxi includes decontamination measures, ventilatory support, and pharmacological treatment, which includes the use of atropine, pralidoxime, and diazepam. In addition, it is supported by the use of rhubarb as an adjuvant. Proper management of these patients can mean the difference between life and death, so it is important that all emergency personnel are trained to recognize the clinical picture.


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