2020, Number 2
Comparación del desempeño de un dispositivo basado en detección vía anticuerpos vs Quantiferon TB gold in tube para diagnóstico de tuberculosis en pacientes con diabetes mellitus
Full text
Language: Spanish
References: 14
Page: 103-112
PDF size: 300.78 Kb.
ABSTRACT
Tuberculosis (TB) leads to about 1.3 million deaths per year in the world, along with 10 million new cases per year. One of the risk factors for the development of pulmonary TB is diabetes mellitus (DM), where, in Mexico, an estimated 25% of diabetic patients simultaneously suffer from TB. Since the TB / DM comorbidity makes it difficult to treat both conditions, WHO and the International Union against Tuberculosis and Pulmonary Disease recommend examining patients with newly diagnosed TB for diabetes and considering detecting TB in diabetic patients. In previous reports, IGRAs have been found to have difficulties in diagnosing TB in diabetic populations. Based on this, in this work the sensitivity of a test developed by a Jalisco´s company to detect TB in patients with DM was evaluated and compared with the Quantiferon TB gold in tube standard. Our results show that DM reduces the sensitivity of QFT and that the test developed by a Jalisco´s company presents sensitivity values and diagnostic specificity of TB in acceptable range according to WHO criteria in people without DM.REFERENCES
Faurholt Jepsen, Daniel & Aabye, Martine & Jensen, Andreas & Range, Nyagosya & Praygod, George & Jeremiah, Kidola & Changalucha, John & Faurholt Jepsen, Maria & Jensen, Lotte & Jensen, Signe & Krarup, Henrik & Ravn, Pernille & Friis, Henrik & Andersen, Ase. (2014). Diabetes is associated with lower tuberculosis antigen-specifi c interferon gamma release in Tanzanian tuberculosis patients and non-tuberculosis controls. Scandinavian journal of infectious diseases. 46. 10.3109/00365548.2014.885657.
Jimenez Corona, M. E., Cruz Hervert, L. P., Garcia Garcia, L., Ferreyra Reyes, L., Delgado Sanchez, G., Bobadilla Del Valle, M., . . . Ponce de Leon, A. (2013). Association of diabetes and tuberculosis: impact on treatment and posttreatment outcomes. Th orax, 68(3), 214-220. doi:10.1136/ thoraxjnl-2012-201756
López Ramos, J. E., Macías Segura, N., Cuevas Cordoba, B., Araujo Garcia, Z., Bastián, Y., Castañeda Delgado, J. E., ... & Enciso Moreno, J. A. (2018). Improvement in the diagnosis of tuberculosis combining Mycobacterium tuberculosis immunodominant peptides and serum host biomarkers. Archives of medical research, 49(3), 147-153.
Penuelas Urquides, K., Martinez-Rodriguez, H. G., Enciso Moreno, J. A., Molina Salinas, G. M., Silva Ramirez, B., Padilla Rivas, G. R., . . . Said Fernandez, S. (2014). Correlations between major risk factors and closely related Mycobacterium tuberculosis isolates grouped by three current enotyping procedures: a population-based study in northeast Mexico. Memorias do Instituto Oswaldo Cruz, 109(6), 814-819.