medigraphic.com
ISSN 1608-8921 (Print)

2019, Number 3

<< Back Next >>

Gaceta Médica Espirituana 2019; 21 (3)

Nasopharyngeal carcinoma and its relationship with the Epstein-Barr virus, clinical and epidemiological description

Fonseca PAJ, González FN, Pérez VM, Rocha RP, Rodríguez TA

Language: Spanish
References: 22
Page: 101-111
PDF size: 138.98 Kb.


ABSTRACT

Background: Nasopharyngeal carcinoma is the most common malignant tumor of the cavum. These tumors differ from some other epidermoid carcinomas of the head and neck by their histology features and their Epstein-Barr virus relationship.
Objective: To describe clinically and epidemiologically the nasopharyngeal carcinoma and its relationship with the Epstein-Barr virus, at the National Institute of Oncology and Radiobiology, Havana City, from January to December 2012.
Methodology: A retrospective study was conducted; with a total of 16 medical records. Variables such as age, sex, histological type, clinical staging, and presence of Epstein - Barr virus in the tumor, applied treatment, response to treatment, relapse and patient status were observed.
Results: 50% were between 45-55 years old, 75 % were men, 50 % diagnosed with type 3, 100 % negative to Epstein-Barr virus immunohistochemistry, stage III predominated with 43.75 %, 56.25 % of the cases were treated with radio-chemotherapy plus chemotherapy, 50 % had a complete response, relapse was 37.50 % and at 60 months 68.75 % of the patients were still alive.
Conclusions: In this small population with nasopharyngeal carcinoma, the entire population was negative to the presence of Epstein-Barr virus applying immunohistochemical techniques, so its negativity became representative in type 3 and advanced stages and had no impact on the treatment response and overall survival.


REFERENCES

  1. Alcalde J, Basterra J, Rey J, Ruba D. Carcinoma de rinofaringe. En: Basterra J. Carcinomas de faringe. Badalona: Euromedice Ediciones Médicas; 2007.p.59-100.

  2. Adham M, Kurniawan AN, Muhtadi AI, Roezin A, Hermani B, Gondhowiardjo S, et al. Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chin. j. cancer [Internet]. 2012 [cited 2016 Dec 22];31(4):185-96. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777476/pdf/cjc-31-04-185.pdf

  3. Cortés-Funes H, Colomer Bosch R. Carcinoma de Nasofaringe. En: Cortés-Funes Hernán, Colomer Bosch. Tratado de oncología. Barcelona: P. Permanyer;2009.p.209-23

  4. Suárez Nieto C, Gil-Carcedo García LM, Algarra JM, Medina JE, Ortega del Álamo P, Trinidad Pinedo J. Tratado de otorrinolaringología y cirugía de cabeza y cuello. Madrid: Editorial Médica Panamericana; 2009. 3162 p.

  5. Lalwani Anil K. Diagnóstico y tratamiento en otorrinolaringología. Cirugía de cabeza y cuello. 2.a ed. New York: McGraw-Hill; 2009.1028.p.

  6. Arredondo López M, Rodríguez Abreu D, Michuli Roca, Salazar S. Guías de Diagnóstico y Tratamiento en Oncología. Carcinoma de nasofaringe [Internet]. La Habana: Instituto de oncología; 2002. [citado 11 jul 2017]. Disponible en: http://files.sld.cu/oncologia/files/2010/03/nasofaringe.pdf

  7. Lu JJ, Cooper JS, Lee AWM. Nasopharyngeal Cancer: Multidisciplinary Management [Internet]. New York: Springer Berlin Heidelberg; 2010 [cited 2017 Ago 11]. 320.p. Available from: http://link.springer.com/10.1007/978-3-540-92810-2

  8. Baert AL, Brady LW, Heilmann HP, Knauth M, Molls M, Nieder C, et al. Nasopharyngeal Cancer.1ra ed. New York. Springer Heidelberg Dordrecht;2010.

  9. Pérez Plasencia D, Gómez González JL, Santa Cruz Ruiz S, Muñoz Herrera A, Mateos Pérez Flores T, Pardal JL. Estudio clínico descriptivo de 40 pacientes con Carcinoma de Nasofaringe en estadio avanzado en un área de bajo riesgo epidemiológico. Acta Otorrinolaringol Esp [Internet]. 2002 [citado 11 ago 2016];53: 473-480. Disponible en: https://www.elsevier.es/es-revista-acta-otorrinolaringologica-espanola-102-pdf-S0001651902783398

  10. Adham M, Kurniawan AN, Muhtadi AI, Roezin A, Hermani B, Gondhowiardjo S, et al. Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chin J Cancer [Internet]. 2012 [cited 2016 Jul 20];31(4):185-96. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777476/

  11. Zhang N, Liang SB, Deng YM, Lu RL, Chen HY, Zhao H, et al. Primary tumor regression speed after radiotherapy and its prognostic significance in nasopharyngeal carcinoma: a retrospective study. BMC Cance [Internet]. 2014 [cited 2016 May 24];14:136. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943409/

  12. Ozyar E, Dizman A, Esassolak M, Ikizler A, Yildirim C, Caloglu M, et al. Patterns of Care Study in Turkish Nasopharyngeal Cancer Patients (NAZOTURK): A Turkish Radiation Oncology Association Head and Neck Cancer Working Group Study. International Journal of Radiation Oncology Biology Physics [Internet]. 1 de noviembre de 2015 [cited 2016 Nov 22];93(3):E314. Available from: https://doi.org/10.1016/j.ijrobp.2015.07.1346

  13. Kong F, Cai B-Z, Chen X-Z, Zhang J, Wang Y-M. Prognostic factors for survival of patients with nasopharyngeal carcinoma following conventional fractionation radiotherapy. Experimental and Therapeutic Medicine [Internet]. julio de 2013 [cited 2016 Nov 22];6(1):57-60. Available from: https://www.spandidos-publications.com/10.3892/etm.2013.1100

  14. Instituto Nacional del Cáncer. Cancer de nasofaringe [Internet]. Chicago: INC;2015. [citado 11 jul 2017]. [Actualizado 2015 jul 13]. Disponible en: http://www.cancer.gov/espanol/tipos/cabeza-cuello/pro/tratamiento-nasofaringe-pdf.

  15. Escamilla Carpintero Y, Aguilà Artal AF, Bonfill Abella T, Mur Restoy E, Díaz Argüello JJ. Carcinoma nasofaringeo. Revisión retrospectiva de 23 años en nuestro centro. ORL Aragon [Internet]. 2015 [citado 11 jul 2017];18(1):15-20. Disponible en: http://www.saorl.org/catalogo.aspx?idArea=40&idPadre=0&idNodo=138&idParrafo=441

  16. Coscarón Blanco E, Martín Garrido EP. Carcinoma epidermoide de nasofaringe. Jano [Internet] 2011 [citado 11 jul 2017]:45-53. Disponible en: https://studylib.es/doc/6072872/carcinoma-epidermoide-de-nasofaringe

  17. Li JX, Lu TX, Huang Y, Han F. Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area. The Scientific World Journal [Internet]. 2012 [cited 2016 Nov 22];2012:1-8. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289855/

  18. Spratt DE, Lee N. Current and emerging treatment options for nasopharyngeal carcinoma. OncoTargets ther. [Internet]. octubre de 2012 [cited 2016 Nov 22]5;297-308. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484899/pdf/ott-5-297.pdf

  19. Zúñiga Orlich A, Rodríguez Rodríguez C, Gamboa Chaves AY. Características clínico-epidemiológicas de los pacientes con diagnóstico de carcinoma nasofaríngeo. Rev Méd Costa Rica Centroamérica [Internet]. 2016 [citado 29 de enero de 2018];73(618):41-8. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=66643

  20. Moreno M, Salgado E, Azinovic I, Cañón RM, López-Picazo JM, Beltrán C, et al. Carcinoma de nasofaringe localmente avanzado: resultados finales del tratamiento de quimiorradioterapia seguido de quimioterapia complementaria. Rev Oncología [Internet]. 2000 [citado 2015 jul 12];2:301-30. Disponible en: https://link.springer.com/content/pdf/10.1007%2FBF02979593.pdf

  21. Tan I, Chang ET, Chen C-J, Hsu W-L, Chien Y-C, Hildesheim A, et al. Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015. BMC Proceedings [Internet]. 2016 [cited 2016 Nov 22];10(S1). Available from: http://bmcproc.biomedcentral.com/articles/10.1186/s12919-016-0001-5

  22. Tsang CM, Deng W, Yip YL, Zeng MS, Lo KW, Tsao SW, et al. Epstein Barr Virus infection an persistence in nasopharyngeal epithelial cells. Chin. j. cancer [Internet]. 2014 [cited 2016 Nov 22];33(11):549-55. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244318/




2020     |     www.medigraphic.com